Effect of LMP-1 expression on FFS and OS of patients with cHL after stratification with respect to age
Outcome measure . | All ages . | 14-34 y . | 35-49 y . | 50 y and older . |
|---|---|---|---|---|
| All patients, no. of all patients/failures/deaths | 575/126/115 | 356/74/45 | 134/28/25 | 85/24/45 |
| 10-y FFS, LMP-1+ vs LMP-1– | 77% ± 4% vs 78% ± 2%, P = .68 | 78% ± 5% vs 79% ± 2%, P = .60 | 82% ± 7% vs 77% ± 5%, P = .62 | 70% ± 9% vs 70% ± 6%, P = .89 |
| 10-y OS, LMP-1+ vs LMP-1– | 78% ± 4% vs 81% ± 2%, P = .04 | 91% ± 4% vs 87% ± 2%, P = .69 | 83% ± 7% vs 82% ± 4%, P = .82 | 46% ± 10% vs 48% ± 7%, P = .56 |
| ABVD and equivalent with or without radiotherapy: no. of patients/failures/deaths | 303/65/57 | 194/40/28 | 66/11/7 | 43/14/22 |
| 10-y FFS, LMP-1+ vs LMP-1– | 73% ± 6% vs 80% ± 3%, P = .26 | 72% ± 9% vs 81% ± 3%, P = 0.25 | 83% ± 9% vs 82% ± 6%, P = .97 | 65% ± 12% vs 68% ± 9%, P = .95 |
| 10-y OS, LMP-1+ vs LMP-1– | 77% ± 6% vs 80% ± 3%, P = .56 | 92% ± 6% vs 82% ± 4%, P = .61 | 85% ± 10% vs 89% ± 5%, P = .95 | 50% ± 13% vs 49% ± 11%, P = .56 |
Outcome measure . | All ages . | 14-34 y . | 35-49 y . | 50 y and older . |
|---|---|---|---|---|
| All patients, no. of all patients/failures/deaths | 575/126/115 | 356/74/45 | 134/28/25 | 85/24/45 |
| 10-y FFS, LMP-1+ vs LMP-1– | 77% ± 4% vs 78% ± 2%, P = .68 | 78% ± 5% vs 79% ± 2%, P = .60 | 82% ± 7% vs 77% ± 5%, P = .62 | 70% ± 9% vs 70% ± 6%, P = .89 |
| 10-y OS, LMP-1+ vs LMP-1– | 78% ± 4% vs 81% ± 2%, P = .04 | 91% ± 4% vs 87% ± 2%, P = .69 | 83% ± 7% vs 82% ± 4%, P = .82 | 46% ± 10% vs 48% ± 7%, P = .56 |
| ABVD and equivalent with or without radiotherapy: no. of patients/failures/deaths | 303/65/57 | 194/40/28 | 66/11/7 | 43/14/22 |
| 10-y FFS, LMP-1+ vs LMP-1– | 73% ± 6% vs 80% ± 3%, P = .26 | 72% ± 9% vs 81% ± 3%, P = 0.25 | 83% ± 9% vs 82% ± 6%, P = .97 | 65% ± 12% vs 68% ± 9%, P = .95 |
| 10-y OS, LMP-1+ vs LMP-1– | 77% ± 6% vs 80% ± 3%, P = .56 | 92% ± 6% vs 82% ± 4%, P = .61 | 85% ± 10% vs 89% ± 5%, P = .95 | 50% ± 13% vs 49% ± 11%, P = .56 |
No difference was statistically significant in the multivariate analysis after adjustment for age (all ages subgroup), sex, and stage (early IA, IIA versus advanced IB, IIB, III, IV).