Penetrance and mean age of onset of clinical symptoms in homozygous Lupo mutant mice on C3HeB/FeJ (C3H), C3HeB/FeJ × C57BL/6J (C3H/BL6), and C3H/BL6; Rag1-/- backgrounds
Parameter . | C3H . | C3H/BL6 . | C3H/BL6; Rag1–/– . |
|---|---|---|---|
| Lupo homozygotes, no. | 51 | 57 | 17 |
| Median age of onset, d | 42 ± 4* | 124 ± 92* | 43 ± 9* |
| Penetrance, % | 98 | 52 | 88 |
Parameter . | C3H . | C3H/BL6 . | C3H/BL6; Rag1–/– . |
|---|---|---|---|
| Lupo homozygotes, no. | 51 | 57 | 17 |
| Median age of onset, d | 42 ± 4* | 124 ± 92* | 43 ± 9* |
| Penetrance, % | 98 | 52 | 88 |
Penetrance was scored at 65 days or more and was tested by χ2 analysis and Fisher exact test. P < .01 for C3H/BL6 compared with C3H and for C3H/BL6 compared with C3H/BL6 Rag1–/– mice.
95% confidence limits (Cls)