SHIP-2 down-regulates FcγR-mediated phagocytosis in SHIP-1−/− BMMs
. | Phagocytic index, mean of 3 readings ± SD . | P, compared with empty vector transfectants . |
|---|---|---|
| Experiment 1 | ||
| Vector | 163.00 ± 20.66 | — |
| WT-SHIP-2 | 122.33 ± 11.24 | .018 |
| D608A-SHIP-2 | 261.00 ± 16.09 | .017 |
| Experiment 2 | ||
| Vector | 247.67 ± 23.12 | — |
| WT-SHIP-2 | 185.67 ± 8.74 | .019 |
| D608A-SHIP-2 | 355.33 ± 28.22 | <.001 |
| Experiment 3 | ||
| Vector | 202.00 ± 3.00 | — |
| WT-SHIP-2 | 151.33 ± 3.75 | .002 |
| D608A-SHIP-2 | 299.00 ± 9.97 | <.001 |
. | Phagocytic index, mean of 3 readings ± SD . | P, compared with empty vector transfectants . |
|---|---|---|
| Experiment 1 | ||
| Vector | 163.00 ± 20.66 | — |
| WT-SHIP-2 | 122.33 ± 11.24 | .018 |
| D608A-SHIP-2 | 261.00 ± 16.09 | .017 |
| Experiment 2 | ||
| Vector | 247.67 ± 23.12 | — |
| WT-SHIP-2 | 185.67 ± 8.74 | .019 |
| D608A-SHIP-2 | 355.33 ± 28.22 | <.001 |
| Experiment 3 | ||
| Vector | 202.00 ± 3.00 | — |
| WT-SHIP-2 | 151.33 ± 3.75 | .002 |
| D608A-SHIP-2 | 299.00 ± 9.97 | <.001 |
Three representative experiments are shown.
—indicates not applicable.