Receptor-ligand mismatch
Father KIR . | Corresponding ligand(s) in patient . |
|---|---|
| 2DL1+ | HLA-CLys80 (Cw*04, Cw*05) |
| 2DL3+ | No cognate ligand in patient |
| 3DL1+ | HLA-Bw4 (B*53, B*44) |
Father KIR . | Corresponding ligand(s) in patient . |
|---|---|
| 2DL1+ | HLA-CLys80 (Cw*04, Cw*05) |
| 2DL3+ | No cognate ligand in patient |
| 3DL1+ | HLA-Bw4 (B*53, B*44) |
Recipient HLA and donor KIR typing demonstrated the absence of HLA-CAsn80 ligand in the patient for KIR2DL3, which was present in the donor. This leads to a prediction of NK-cell alloreactivity by the KIR receptor-ligand model.