General phenotypes of mice of the Csf1op/Csf1op; TgSPP/+ and Csf1op/Csf1op; TgSGP/+ lines
. | Transgenic correction of Csf1op/Csf1op phenotype at 2 mo* . | . | . | . | . | . | . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | . | F4/80+ cell densities . | . | . | . | ||||||||
| Founder . | OP . | FL . | EPL . | TPC . | IE, d . | L . | S . | K . | BM . | ||||||||
| wt | 4 | 4 | 4 | 4 | 7-8 | 4 | 4 | 4 | 4 | ||||||||
| Csf1op/Csf1op | 0 | 0 | 0 | 0 | ∞ | 0 | 0 | 0 | 0 | ||||||||
| TgSPP2 | 4 | 4 | 4 | 4 | 7-8 | 3 | 4 | 4 | 4 | ||||||||
| TgSPP7 | 4 | 4 | 4 | 4 | 7-8 | 2 | 3 | 2 | 4 | ||||||||
| TgSPP8† | 4 | 4 | 4 | 4 | 7-8 | 4 | 3 | 3 | 3 | ||||||||
| TgSPP10 | 4 | 4 | 4 | 4 | 7-8 | 4 | 3 | 4 | 3 | ||||||||
| TgSPP11‡ | 4 | 4 | 4 | 4 | 7-8 | 4 | 4 | 3 | 4 | ||||||||
| TgSPP13 | 4 | 4 | 4 | 4 | 7-8 | 3 | 3 | 3 | 3 | ||||||||
| TgSGP2 | 4 | 3.5 | 4 | 4 | 7-8 | 3 | 3 | 4 | 4 | ||||||||
| TgSGP4 | 1 | 2 | 2 | 7 | 12-13 | 4 | 3 | 2 | 3 | ||||||||
| TgSGP5 | 3 | 4 | 3 | 4 | 7-8 | 4 | 3.5 | 3 | 3.5 | ||||||||
| TgSGP6 | 3 | 4 | 4 | 6 | 9-10 | 2 | 2 | 3 | 3 | ||||||||
. | Transgenic correction of Csf1op/Csf1op phenotype at 2 mo* . | . | . | . | . | . | . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | . | F4/80+ cell densities . | . | . | . | ||||||||
| Founder . | OP . | FL . | EPL . | TPC . | IE, d . | L . | S . | K . | BM . | ||||||||
| wt | 4 | 4 | 4 | 4 | 7-8 | 4 | 4 | 4 | 4 | ||||||||
| Csf1op/Csf1op | 0 | 0 | 0 | 0 | ∞ | 0 | 0 | 0 | 0 | ||||||||
| TgSPP2 | 4 | 4 | 4 | 4 | 7-8 | 3 | 4 | 4 | 4 | ||||||||
| TgSPP7 | 4 | 4 | 4 | 4 | 7-8 | 2 | 3 | 2 | 4 | ||||||||
| TgSPP8† | 4 | 4 | 4 | 4 | 7-8 | 4 | 3 | 3 | 3 | ||||||||
| TgSPP10 | 4 | 4 | 4 | 4 | 7-8 | 4 | 3 | 4 | 3 | ||||||||
| TgSPP11‡ | 4 | 4 | 4 | 4 | 7-8 | 4 | 4 | 3 | 4 | ||||||||
| TgSPP13 | 4 | 4 | 4 | 4 | 7-8 | 3 | 3 | 3 | 3 | ||||||||
| TgSGP2 | 4 | 3.5 | 4 | 4 | 7-8 | 3 | 3 | 4 | 4 | ||||||||
| TgSGP4 | 1 | 2 | 2 | 7 | 12-13 | 4 | 3 | 2 | 3 | ||||||||
| TgSGP5 | 3 | 4 | 3 | 4 | 7-8 | 4 | 3.5 | 3 | 3.5 | ||||||||
| TgSGP6 | 3 | 4 | 4 | 6 | 9-10 | 2 | 2 | 3 | 3 | ||||||||
OP indicates osteopetrosis; FL, femur length; EPL, epiphyseal plate length; TPC, TRAP-positive cells; IE, incisor eruption; L, liver; S, spleen; K, kidney; and BM, bone marrow.
From X-ray measurements, histochemistry, and immunohistochemistry. Correction assessed using an arbitrary scale (for each trait, wt = 4 and Csf1op/Csf1op = 0). Of a total of 19 founder mice (13 TgSPP and 6 TgSGP), 6 transgenes (TgSPP1, TgSPP4, TgSPP5, TgSPP6, TgSPP9, TgSGP1) were not transmissible and 3 (TgSPP3, TgSPP12, TgSGP3) were not transmissible on the Csf1op/Csf1op background.
Non-Mendelian transmission on the Csf1op/Csf1op background.
Lower rate of fertility.