Table 1.

Effect of sTF, sTF-annexin V, and sTFAA-annV on the rate of factor X activation by factor VIIa


Cofactor

Vmax, nM × min–1

Km, nM

kcat, s–1

kcat/Km, μM–1s–1
TF   0.71 ± 0.008   46 ± 1   2.37   51.5  
sTF-annV   0.66 ± 0.03   64 ± 7   2.2   34.4  
sTFAA-annV
 
0.71 ± 0.06
 
389 ± 58
 
2.37
 
6.1
 

Cofactor

Vmax, nM × min–1

Km, nM

kcat, s–1

kcat/Km, μM–1s–1
TF   0.71 ± 0.008   46 ± 1   2.37   51.5  
sTF-annV   0.66 ± 0.03   64 ± 7   2.2   34.4  
sTFAA-annV
 
0.71 ± 0.06
 
389 ± 58
 
2.37
 
6.1
 

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