Reactivation of latent HCMV from myeloid progenitor cells by coculture with permissive HFs
. | Day after coculture at which cytopathic effect (CPE) is first detected . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Days after infection . | HCMV-infected myeloid progenitor cells (frequency of reactivation*) . | HCMV-infected myeloid progenitor cell lysate . | Mock-infected myeloid progenitor cells . | Mock-infected myeloid progenitor cell lysate . | HCMV-infected HF cells, productive infection . | Mock-infected HF cells . | |||||
| 1 | 14 (1.4 × 10-3) | No CPE | No CPE | No CPE | 3 | No CPE | |||||
| 2 | 13 (1.3 × 10-3) | No CPE | No CPE | No CPE | 2 | No CPE | |||||
| 3 | 13 (5.8 × 10-4) | No CPE | No CPE | No CPE | 1 | No CPE | |||||
| 5 | 11 (2.8 × 10-4) | No CPE | No CPE | No CPE | 1 | No CPE | |||||
| 11 | 10 (1.8 × 10-4) | No CPE | No CPE | No CPE | Not done | No CPE | |||||
. | Day after coculture at which cytopathic effect (CPE) is first detected . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Days after infection . | HCMV-infected myeloid progenitor cells (frequency of reactivation*) . | HCMV-infected myeloid progenitor cell lysate . | Mock-infected myeloid progenitor cells . | Mock-infected myeloid progenitor cell lysate . | HCMV-infected HF cells, productive infection . | Mock-infected HF cells . | |||||
| 1 | 14 (1.4 × 10-3) | No CPE | No CPE | No CPE | 3 | No CPE | |||||
| 2 | 13 (1.3 × 10-3) | No CPE | No CPE | No CPE | 2 | No CPE | |||||
| 3 | 13 (5.8 × 10-4) | No CPE | No CPE | No CPE | 1 | No CPE | |||||
| 5 | 11 (2.8 × 10-4) | No CPE | No CPE | No CPE | 1 | No CPE | |||||
| 11 | 10 (1.8 × 10-4) | No CPE | No CPE | No CPE | Not done | No CPE | |||||
No CPE indicates no cytopathic effect observed after 20 days coculture with permissive HFs.
Frequency of myeloid progenitors that reactivate and produce infectious virus, determined by infectious center assay.