Table 1. Serum immunoglobulin and IgG... | American Society of Hematology

Table 1.

Serum immunoglobulin and IgG subclass levels in ICOS deficiency

	Age at testing, y	IgG, g/L	IgG1, mg/dL	IgG2, mg/dL	IgG3, mg/dL	IgG4, mg/dL	IgA, g/L	IgM, g/L	IgE, IU/mL
Family A
Patient 1	29	< 1.9*	ND	ND	ND	ND	< 0.3*	< 0.2*	< 28
Patient 2	21	4.4*	ND	ND	ND	ND	0.4*	< 0.2*	< 17.5
Family B
Patient 3	35	2.49*	118*	71.7*	21.2*	7*	0.46*	0.26*	< 17.5
Patient 4	25	1.05*	78.2*	10.4*	38.7	< 6*	< 0.06*	0.31*	< 17.5
Family C
Patient 5	46	1.01*	< 2.8*	66.9*	44.9	< 0.72*	< 0.06*	0.38*	< 17.5
Patient 6	42	0.57*	ND	ND	ND	ND	< 0.06*	1.8	< 19.1
Family D
Patient 7	15	2.55*	181*	36*	38	0*	< 0.25*	0.26*	< 30
Patient 8	4	2.13*	118*	10*	11*	0*	0.58*	0.57	ND
Patient 9	3	0.54*	50*	20*	4*	0*	0.2*	0.43	< 17.5
Normal range	—	7.0-16	360-940	170-550	30-120	6-120	0.7-4	0.4-2.3	< 100

	Age at testing, y	IgG, g/L	IgG1, mg/dL	IgG2, mg/dL	IgG3, mg/dL	IgG4, mg/dL	IgA, g/L	IgM, g/L	IgE, IU/mL
Family A
Patient 1	29	< 1.9*	ND	ND	ND	ND	< 0.3*	< 0.2*	< 28
Patient 2	21	4.4*	ND	ND	ND	ND	0.4*	< 0.2*	< 17.5
Family B
Patient 3	35	2.49*	118*	71.7*	21.2*	7*	0.46*	0.26*	< 17.5
Patient 4	25	1.05*	78.2*	10.4*	38.7	< 6*	< 0.06*	0.31*	< 17.5
Family C
Patient 5	46	1.01*	< 2.8*	66.9*	44.9	< 0.72*	< 0.06*	0.38*	< 17.5
Patient 6	42	0.57*	ND	ND	ND	ND	< 0.06*	1.8	< 19.1
Family D
Patient 7	15	2.55*	181*	36*	38	0*	< 0.25*	0.26*	< 30
Patient 8	4	2.13*	118*	10*	11*	0*	0.58*	0.57	ND
Patient 9	3	0.54*	50*	20*	4*	0*	0.2*	0.43	< 17.5
Normal range	—	7.0-16	360-940	170-550	30-120	6-120	0.7-4	0.4-2.3	< 100

ND indicates not determined; —, not applicable.

Pathologic value.