Detection of new natural products that enhance sensitivity to TRAIL
. | . | Concentration of materials, μg/mL . | Cell proliferation, % of control . | . | |
|---|---|---|---|---|---|
| Material . | Plant . | . | TRAIL- . | TRAIL+ . | |
| Voaphylline | Tabernaemontana divaricata | 25 | 71 | 38 | |
| Voafinine | T divaricata | 25 | 79 | 44 | |
| Vincadifformine | Kopsia arborea | 12.5 | 95 | 57 | |
| 5.21-dihydrorhazinilam | K arborea | 3.1 | 67 | 50 | |
| Rhazimal | K arborea | 12.5 | 80 | 51 | |
| Methyldihyroquercetin (BB-1) | Blumera basamifera | 12.5 | 96 | 41 | |
. | . | Concentration of materials, μg/mL . | Cell proliferation, % of control . | . | |
|---|---|---|---|---|---|
| Material . | Plant . | . | TRAIL- . | TRAIL+ . | |
| Voaphylline | Tabernaemontana divaricata | 25 | 71 | 38 | |
| Voafinine | T divaricata | 25 | 79 | 44 | |
| Vincadifformine | Kopsia arborea | 12.5 | 95 | 57 | |
| 5.21-dihydrorhazinilam | K arborea | 3.1 | 67 | 50 | |
| Rhazimal | K arborea | 12.5 | 80 | 51 | |
| Methyldihyroquercetin (BB-1) | Blumera basamifera | 12.5 | 96 | 41 | |
KOB cells (3.5 × 105/mL) were incubated for 48 hours with 0.5 μg/mL TRAIL and various concentrations of natural products; this was followed by assessment of cell proliferation using Alamar Blue bioassay.