Overview of the germ-line segments used for the immunoglobulin gene rearrangements and of the somatic mutations in the 7 MALT lymphomas
Patient . | VH segment . | VH family . | JH segment . | Intraclonal diversity VH . | Antigen selection* . | VL segment . | VL family . | JL segment . | Intraclonal diversity VL . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | VH3-23 | VH 3 | JH 4 | No | Yes/Yes | IGKV3-20 | VK 3 | JK 1 | No |
| 2 | VH3-07 | VH 3 | JH 4 | No | No/NA | IGKV4-01 | VK 4 | JK 1 | No |
| 3 | VH3-07 | VH 3 | JH 3 | Yes | Yes/NA | IGKV3-15 | VK 3 | JK 1 | No |
| 4 | VH3-23 | VH 3 | JH 4 | Yes | Yes/No | IGKV1-09 | VK 1 | JK 4 | No |
| 5 | VH4-59 | VH 4 | JH 6 | Yes | No/NA | IGLV2-23 | VL 2 | JL 3 | Yes |
| 6 | VH1-02 | VH 1 | JH 4 | No | Yes/No | IGLV3-19 | VL 3 | JL 1 | No |
| 7 | VH1-69 | VH 1 | JH 6 | Yes | No/No | IGKV3-20 | VK 3 | JK 1 | Yes |
Patient . | VH segment . | VH family . | JH segment . | Intraclonal diversity VH . | Antigen selection* . | VL segment . | VL family . | JL segment . | Intraclonal diversity VL . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | VH3-23 | VH 3 | JH 4 | No | Yes/Yes | IGKV3-20 | VK 3 | JK 1 | No |
| 2 | VH3-07 | VH 3 | JH 4 | No | No/NA | IGKV4-01 | VK 4 | JK 1 | No |
| 3 | VH3-07 | VH 3 | JH 3 | Yes | Yes/NA | IGKV3-15 | VK 3 | JK 1 | No |
| 4 | VH3-23 | VH 3 | JH 4 | Yes | Yes/No | IGKV1-09 | VK 1 | JK 4 | No |
| 5 | VH4-59 | VH 4 | JH 6 | Yes | No/NA | IGLV2-23 | VL 2 | JL 3 | Yes |
| 6 | VH1-02 | VH 1 | JH 4 | No | Yes/No | IGLV3-19 | VL 3 | JL 1 | No |
| 7 | VH1-69 | VH 1 | JH 6 | Yes | No/No | IGKV3-20 | VK 3 | JK 1 | Yes |
VH indicates variable segment of the heavy chain; JH, joining segment of the heavy chain; VL, variable segment of the light chain; JL joining segment of the light chain; and NA, number of mutations too low for calculation of antigen selection.
Based on the multinomial model and/based on the ratio of replacement to silent mutations