Cotransplantation of CTLA-4-/- bone marrow does not recapitulate autoimmunity
Mixed bone marrow chimeras . | Incidence of vitiligo, no./total no. . | P . |
|---|---|---|
| WT/WT | 0/8 | RP |
| pmel-1+/CTLA-4-/- | 2/8 | > .05 |
| WT/CTLA-4-/- | 1/8 | > .05 |
| pmel-1+/WT | 0/8 | > .05 |
Mixed bone marrow chimeras . | Incidence of vitiligo, no./total no. . | P . |
|---|---|---|
| WT/WT | 0/8 | RP |
| pmel-1+/CTLA-4-/- | 2/8 | > .05 |
| WT/CTLA-4-/- | 1/8 | > .05 |
| pmel-1+/WT | 0/8 | > .05 |
C57BL/6 mice were lethally irradiated (1000 cGy) and reconstituted with a 1:1 mix of bone marrow cells from WT or pmel-1 mice and WT or CTLA4-/- mice. Two months later the development of vitiligo was blindly evaluated. No statistically significant differences were observed between each group.
RP indicates reference point for the other groups.