CTLA-4-/- CD8+ T cells alone do not trigger vitiligo
Genotype . | Incidence of vitiligo, no./total no. . | P . |
|---|---|---|
| pmel-1+ Rag+/-;+/+ CTLA-4-/- | 26/26 | RP |
| pmel-1+ Rag-/- CTLA-4-/- | 0/28 | < .001 |
| pmel-1- Rag-/- CTLA-4-/- | 0/47 | < .001 |
| pmel-1- Rag+/-;+/+ CTLA-4+/-;+/+ | 0/89 | < .001 |
Genotype . | Incidence of vitiligo, no./total no. . | P . |
|---|---|---|
| pmel-1+ Rag+/-;+/+ CTLA-4-/- | 26/26 | RP |
| pmel-1+ Rag-/- CTLA-4-/- | 0/28 | < .001 |
| pmel-1- Rag-/- CTLA-4-/- | 0/47 | < .001 |
| pmel-1- Rag+/-;+/+ CTLA-4+/-;+/+ | 0/89 | < .001 |
Prior to genotyping, at 6 weeks of age mice were blindly scored for the presence of vitiligo. In the absence of rag-1 gene expression, pmel-1 Rag-/- CTLA-4-/- mice do not develop vitiligo.
RP indicates reference point for the other groups.