CTLA-4-/- pmel-1+ mice develop accelerated vitiligo
Genotype . | Incidence of vitiligo, no./total no. . | P . |
|---|---|---|
| pmel-1+ CTLA-4-/- | 48/49 | RP |
| pmel-1+ CTLA-4+/+ | 0/153 | < .001 |
| pmel-1- CTLA-4-/- | 1/6 | < .001 |
| pmel-1- CTLA-4+/-;+/+ | 0/19 | < .001 |
Genotype . | Incidence of vitiligo, no./total no. . | P . |
|---|---|---|
| pmel-1+ CTLA-4-/- | 48/49 | RP |
| pmel-1+ CTLA-4+/+ | 0/153 | < .001 |
| pmel-1- CTLA-4-/- | 1/6 | < .001 |
| pmel-1- CTLA-4+/-;+/+ | 0/19 | < .001 |
Prior to genotyping, mice at 6 weeks of age were blindly scored for the presence of vitiligo. Development of vitiligo is dependent on both the expression of the pmel-1 transgene and the lack of cell-surface CTLA-4 expression.
RP indicates reference point for the other groups.