Table 3. Biologic characteristics of 90... | American Society of Hematology

Table 3.

Biologic characteristics of 90 adults with T-ALL

Characteristic	Value
Immunophenotype, %*
T-I (pro-T)	4
T-II (pre-T)	47
T-III (cortical-T)	39
T-IV (mature-T)	10
Cytogenetics, no. (%)
Unsuccessful karyotype	25/85 (29.4)
Normal karyotype	29/85 (34.1)
Abnormal karyotype	31/85 (36.5)†
Molecular biology, no. (%)
BCR-ABL⁺	1/90 (1)
NUP98-RAP1GDS1⁺	2/90 (2)
CDKN2B⁺/CDKN2A⁺	16/62 (26)
MDR1, no. (%)
P-gp⁺ expression	16/68 (24)
P-gp⁺ function	14/54 (26)

Characteristic	Value
Immunophenotype, %*
T-I (pro-T)	4
T-II (pre-T)	47
T-III (cortical-T)	39
T-IV (mature-T)	10
Cytogenetics, no. (%)
Unsuccessful karyotype	25/85 (29.4)
Normal karyotype	29/85 (34.1)
Abnormal karyotype	31/85 (36.5)†
Molecular biology, no. (%)
BCR-ABL⁺	1/90 (1)
NUP98-RAP1GDS1⁺	2/90 (2)
CDKN2B⁺/CDKN2A⁺	16/62 (26)
MDR1, no. (%)
P-gp⁺ expression	16/68 (24)
P-gp⁺ function	14/54 (26)

30% CD10⁺, 24% CD13⁺ and/or CD33⁺, 34% CD34⁺.

Pseudodiploid, 19/31 (61%); hyperdiploid (47-50 chromosomes), 11/31 (36%); hyperdiploid (> 50 chromosomes), 1/31 (3%).