STAT5A–/– and STAT5A+/+ donor bone marrow populations at baseline (non–5-FU) and after priming with 5-FU
. | STAT5A-/-,% . | . | . | STAT5A+/+,% . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | MAC1+* . | . | . | MAC1+ . | . | . | ||||
. | GR1- . | GR1+ . | B220 . | GR1- . | GR1+ . | B220 . | ||||
| 5-FU | 82 ± 3 | 18 ± 3 | 42 ± 1 | 86 ± 5 | 14 ± 5 | 55 ± 1 | ||||
| Non—5-FU | 32 ± 4 | 68 ± 4 | 32 ± 4 | 32 ± 2 | 68 ± 4 | 33 ± 3 | ||||
. | STAT5A-/-,% . | . | . | STAT5A+/+,% . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | MAC1+* . | . | . | MAC1+ . | . | . | ||||
. | GR1- . | GR1+ . | B220 . | GR1- . | GR1+ . | B220 . | ||||
| 5-FU | 82 ± 3 | 18 ± 3 | 42 ± 1 | 86 ± 5 | 14 ± 5 | 55 ± 1 | ||||
| Non—5-FU | 32 ± 4 | 68 ± 4 | 32 ± 4 | 32 ± 2 | 68 ± 4 | 33 ± 3 | ||||
Results expressed as percent ± SE; n = 3 for each STAT5A genotype.
Immature (MAC1+/GR1-) and mature (MAC1+/GR1+) myeloid cells are expressed as a percentage of total MAC1+ cells.