Multivariate proportional-hazards analysis of the risk of relapse: validation SJCRH cohort (N = 92)
. | No. patients . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|---|
| Age at diagnosis, y | ||||
| 1-10 y | 63 | 1.00* | ||
| Older than 10 y | 29 | 7.88 | 1.45-42.9 | .017 |
| WBC count at diagnosis | ||||
| Less than 10 × 109 cells/L | 26 | 1.00* | ||
| 10-49 × 109 cells/L | 26 | 1.06 | 0.21-5.46 | .950 |
| 50-100 × 109 cells/L | 18 | 6.48 | 1.25-33.62 | .026 |
| More than 100 × 109 cells/L | 22 | 2.57 | 0.52-12.64 | .240 |
| Genetic subtype | ||||
| B-lineage | 24 | 1.00* | ||
| Other | ||||
| BCR-ABL | 8 | 5.49 | 1.49-20.23 | .011 |
| E2A rearranged | 12 | 0.70 | 0.07-6.62 | .750 |
| MLL rearranged | 6 | 1.01 | 0.15-6.99 | .990 |
| TEL-AML 1 | 16 | 1.40 | 0.14-14.30 | .780 |
| Hyperdiploid† | 15 | 0.48 | 0.05-4.44 | .510 |
| T-lineage | 9 | 4.85 | 0.64-36.60 | .130 |
| BCL2L13‡ expression | 92 | 4.09 | 0.99-16.78 | .051 |
. | No. patients . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|---|
| Age at diagnosis, y | ||||
| 1-10 y | 63 | 1.00* | ||
| Older than 10 y | 29 | 7.88 | 1.45-42.9 | .017 |
| WBC count at diagnosis | ||||
| Less than 10 × 109 cells/L | 26 | 1.00* | ||
| 10-49 × 109 cells/L | 26 | 1.06 | 0.21-5.46 | .950 |
| 50-100 × 109 cells/L | 18 | 6.48 | 1.25-33.62 | .026 |
| More than 100 × 109 cells/L | 22 | 2.57 | 0.52-12.64 | .240 |
| Genetic subtype | ||||
| B-lineage | 24 | 1.00* | ||
| Other | ||||
| BCR-ABL | 8 | 5.49 | 1.49-20.23 | .011 |
| E2A rearranged | 12 | 0.70 | 0.07-6.62 | .750 |
| MLL rearranged | 6 | 1.01 | 0.15-6.99 | .990 |
| TEL-AML 1 | 16 | 1.40 | 0.14-14.30 | .780 |
| Hyperdiploid† | 15 | 0.48 | 0.05-4.44 | .510 |
| T-lineage | 9 | 4.85 | 0.64-36.60 | .130 |
| BCL2L13‡ expression | 92 | 4.09 | 0.99-16.78 | .051 |
Multivariate Cox regression analysis among 92 patients in the validation SJCRH cohort was performed to quantify the independent contribution of BCL2L13 to disease-free survival. Age, white blood cell (WBC) count and genetic subtype were considered as discrete and BCL2L13 expression as a continuous variable in the analysis. A hazard ratio greater than 1 indicates increased probability of relapse. CI denotes confidence interval.
Reference group.
Cytogenetic analysis revealed more than 50 chromosomes.
Continuous variable.