Multivariate proportional-hazards analysis of the risk of relapse: COALL/DCOG cohort (N = 190)
. | No. patients . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|---|
| Age at diagnosis | ||||
| 1-10 y | 138 | 1.00* | ||
| Older than 10 y | 52 | 1.47 | 0.77-5.13 | .242 |
| WBC count at diagnosis | ||||
| Less than 10 × 109 cells/L | 44 | 1.00* | ||
| 10-49 × 109 cells/L | 71 | 0.56 | 0.21-1.48 | .241 |
| 50-100 × 109 cells/L | 31 | 1.12 | 0.40-3.17 | .827 |
| More than 100 × 109 cells/L | 44 | 1.49 | 0.54-4.06 | .441 |
| Genetic subtype | ||||
| B-lineage | 48 | 1.00* | ||
| Other | ||||
| BCR-ABL | 5 | 1.33 | 0.34-5.13 | .681 |
| E2A rearranged | 9 | 1.10 | 0.31-3.86 | .886 |
| MLL rearranged | 4 | 9.45 | 2.42-36.88 | .001 |
| TEL-AML 1 | 44 | 0.23 | 0.07-0.80 | .021 |
| Hyperdiploid† | 44 | 0.28 | 0.08-0.97 | .045 |
| T-lineage | 36 | 0.66 | 0.28-1.60 | .359 |
| BCL2L13‡ expression | 190 | 1.94 | 1.17-3.24 | .011 |
. | No. patients . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|---|
| Age at diagnosis | ||||
| 1-10 y | 138 | 1.00* | ||
| Older than 10 y | 52 | 1.47 | 0.77-5.13 | .242 |
| WBC count at diagnosis | ||||
| Less than 10 × 109 cells/L | 44 | 1.00* | ||
| 10-49 × 109 cells/L | 71 | 0.56 | 0.21-1.48 | .241 |
| 50-100 × 109 cells/L | 31 | 1.12 | 0.40-3.17 | .827 |
| More than 100 × 109 cells/L | 44 | 1.49 | 0.54-4.06 | .441 |
| Genetic subtype | ||||
| B-lineage | 48 | 1.00* | ||
| Other | ||||
| BCR-ABL | 5 | 1.33 | 0.34-5.13 | .681 |
| E2A rearranged | 9 | 1.10 | 0.31-3.86 | .886 |
| MLL rearranged | 4 | 9.45 | 2.42-36.88 | .001 |
| TEL-AML 1 | 44 | 0.23 | 0.07-0.80 | .021 |
| Hyperdiploid† | 44 | 0.28 | 0.08-0.97 | .045 |
| T-lineage | 36 | 0.66 | 0.28-1.60 | .359 |
| BCL2L13‡ expression | 190 | 1.94 | 1.17-3.24 | .011 |
Multivariate Cox regression analysis among 190 patients of the original COALL/DCOG cohort was performed to quantify the independent contribution of BCL2L13 to disease-free survival. Age, white blood cell (WBC) count and genetic subtype were considered as discrete and BCL2L13 expression as a continuous variable in the analysis. A hazard ratio greater than 1 indicates increased probability of relapse. CI denotes confidence interval.
Reference group.
Cytogenetic analysis revealed more than 50 chromosomes.
Continuous variable.