Clinical and biological patient characteristics
. | COALL/DCOG cohort . | St Jude cohort . |
|---|---|---|
| ALL subtype, no. patients | ||
| B-other | 48 | 27 |
| BCR-ABL | 5 | 8 |
| E2A* | 9 | 12 |
| Hyperdiploid† | 44 | 15 |
| MLL* | 4 | 5 |
| TEL-AML1 | 44 | 17 |
| T-lineage | 36 | 9 |
| Follow-up time, y | ||
| Median | 4.8 | 7.1 |
| Interquartile range | 3.8-5.9 | 4.9-9.0 |
| Age, y | ||
| Median | 6.0 | 6.2 |
| Interquartile range | 3.5-10.2 | 3.3-11.8 |
| WBC, no./nL | ||
| Median | 34.4 | 36.9 |
| Interquartile range | 10.7-89.1 | 8.4-93.3 |
| Clinical response, no. patients | ||
| CCR | 143‡ | 69 |
| Relapse | 45 | 15 |
. | COALL/DCOG cohort . | St Jude cohort . |
|---|---|---|
| ALL subtype, no. patients | ||
| B-other | 48 | 27 |
| BCR-ABL | 5 | 8 |
| E2A* | 9 | 12 |
| Hyperdiploid† | 44 | 15 |
| MLL* | 4 | 5 |
| TEL-AML1 | 44 | 17 |
| T-lineage | 36 | 9 |
| Follow-up time, y | ||
| Median | 4.8 | 7.1 |
| Interquartile range | 3.8-5.9 | 4.9-9.0 |
| Age, y | ||
| Median | 6.0 | 6.2 |
| Interquartile range | 3.5-10.2 | 3.3-11.8 |
| WBC, no./nL | ||
| Median | 34.4 | 36.9 |
| Interquartile range | 10.7-89.1 | 8.4-93.3 |
| Clinical response, no. patients | ||
| CCR | 143‡ | 69 |
| Relapse | 45 | 15 |
This study included 190 samples derived from children with acute lymphoblastic leukemia at diagnosis. CCR indicates continuous complete remission.
COALL: MLL and E2A rearranged; St Jude: MLL-AF4 and E2A-PBX1.
Cytogenetic analysis revealed more than 50 chromosomes.
Two patients had a competing event; a secondary malignancy and myelodysplastic syndrome (MDS).