Effect of ritonavir on infiltration of ATL cells in various organs of SCID mice
Patient no. and treatment . | Liver . | Spleen . | Lung . | Lymph node . |
|---|---|---|---|---|
| 1 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | ++ | + | + | NF |
| 2 | ||||
| Control | +++ | +++ | ++ | +++ |
| Ritonavir | + | + | − | NF |
| 3 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | ± | ± | ± | NF |
| 4 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | + | + | + | NF |
| 5 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | ++ | ++ | ++ | NF |
| 6 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | +++ | ++ | +++ | ++ |
| 7 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | ++ | + | ++ | NF |
| 8 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | ± | ± | ± | NF |
| 9 | ||||
| Control | +++ | +++ | +++ | ++ |
| Ritonavir | ++ | + | + | NF |
| 10 | ||||
| Control | +++ | +++ | ++ | +++ |
| Ritonavir | + | + | + | NF |
Patient no. and treatment . | Liver . | Spleen . | Lung . | Lymph node . |
|---|---|---|---|---|
| 1 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | ++ | + | + | NF |
| 2 | ||||
| Control | +++ | +++ | ++ | +++ |
| Ritonavir | + | + | − | NF |
| 3 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | ± | ± | ± | NF |
| 4 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | + | + | + | NF |
| 5 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | ++ | ++ | ++ | NF |
| 6 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | +++ | ++ | +++ | ++ |
| 7 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | ++ | + | ++ | NF |
| 8 | ||||
| Control | +++ | +++ | +++ | +++ |
| Ritonavir | ± | ± | ± | NF |
| 9 | ||||
| Control | +++ | +++ | +++ | ++ |
| Ritonavir | ++ | + | + | NF |
| 10 | ||||
| Control | +++ | +++ | ++ | +++ |
| Ritonavir | + | + | + | NF |
PBMCs from patients with ATL patients were inoculated subcutaneously into postauricular region of NOG mice, which were treated with ritonavir or RPMI-1640 as a control 1 day after inoculation for 1 month. Various organ infiltration was evaluated 2 months after inoculation.
NF indicates no formation of new lymph node; +++, massive; ++, marked; +, slight; ±, focally present or no infiltration; −, no infiltration.