Human BLT1+ T cells from blood are enriched for early inflammatory chemokine receptors
. | CCR1 . | CXCR1 . | CCR2 . | CXCR3 . | CCR4 . | CXCR4 . | CCR5 . | CCR6 . | CCR7 . |
|---|---|---|---|---|---|---|---|---|---|
| CD4 | |||||||||
| BLT1+, mean ± SD, % | 30.4 ± 11.1 | 33.95 ± 17.1 | 36.5 ± 6.1 | 58.3 ± 12 | 33.2 ± 15.4 | 94.3 ± 6.4 | 29.5 ± 12.8 | 51.4 ± 11.1 | 73.5 ± 13.3 |
| Total, mean ± SD, % | 0.74 ± 0.89 | 1.00 ± 0.47 | 1.5 ± 1.7 | 31.7 ± 8.0 | 25.8 ± 9.2 | 88.9 ± 11.7 | 10.4 ± 2.9 | 28.5 ± 14.9 | 72.6 ± 11.5 |
| P | .001 | <.002 | <.001 | .003 | .34 | .39 | .005 | .025 | .914 |
| Fold enrichment, mean ± SE | 145.2 ± 74.1 | 36.8 ± 8.6 | 90.8 ± 42.1 | 1.9 ± 0.3 | NA | NA | 3.1 ± 0.7 | 4.6 ± 3.1 | NA |
| CD8 | |||||||||
| BLT1+, mean ± SD, % | 17.8 ± 5.4 | 19.7 ± 15.0 | 26.6 ± 6.2 | 87.6 ± 7.5 | 17.4 ± 12.1 | 97.23 ± 2.6 | 40.9 ± 14.3 | 39.2 ± 13.4 | 56.6 ± 7.8 |
| Total, mean ± SD, % | 0.85 ± 1.02 | 2.0 ± 1.4 | 1.6 ± 1.8 | 75.9 ± 9.9 | 5.6 ± 4.5 | 92.3 ± 6.3 | 30.1 ± 9.8 | 21.4 ± 10.4 | 54.3 ± 10.6 |
| P | .001 | .03 | <.001 | .07 | .047 | .15 | .15 | .047 | .7 |
| Fold enrichment, mean ± SE | 79.5 ± 39.2 | 10.7 ± 2.2 | 83.3 ± 38.0 | 1.2 ± 0.1 | 3.8 ± 1.2 | NA | NA | 2.7 ± 1.1 | NA |
. | CCR1 . | CXCR1 . | CCR2 . | CXCR3 . | CCR4 . | CXCR4 . | CCR5 . | CCR6 . | CCR7 . |
|---|---|---|---|---|---|---|---|---|---|
| CD4 | |||||||||
| BLT1+, mean ± SD, % | 30.4 ± 11.1 | 33.95 ± 17.1 | 36.5 ± 6.1 | 58.3 ± 12 | 33.2 ± 15.4 | 94.3 ± 6.4 | 29.5 ± 12.8 | 51.4 ± 11.1 | 73.5 ± 13.3 |
| Total, mean ± SD, % | 0.74 ± 0.89 | 1.00 ± 0.47 | 1.5 ± 1.7 | 31.7 ± 8.0 | 25.8 ± 9.2 | 88.9 ± 11.7 | 10.4 ± 2.9 | 28.5 ± 14.9 | 72.6 ± 11.5 |
| P | .001 | <.002 | <.001 | .003 | .34 | .39 | .005 | .025 | .914 |
| Fold enrichment, mean ± SE | 145.2 ± 74.1 | 36.8 ± 8.6 | 90.8 ± 42.1 | 1.9 ± 0.3 | NA | NA | 3.1 ± 0.7 | 4.6 ± 3.1 | NA |
| CD8 | |||||||||
| BLT1+, mean ± SD, % | 17.8 ± 5.4 | 19.7 ± 15.0 | 26.6 ± 6.2 | 87.6 ± 7.5 | 17.4 ± 12.1 | 97.23 ± 2.6 | 40.9 ± 14.3 | 39.2 ± 13.4 | 56.6 ± 7.8 |
| Total, mean ± SD, % | 0.85 ± 1.02 | 2.0 ± 1.4 | 1.6 ± 1.8 | 75.9 ± 9.9 | 5.6 ± 4.5 | 92.3 ± 6.3 | 30.1 ± 9.8 | 21.4 ± 10.4 | 54.3 ± 10.6 |
| P | .001 | .03 | <.001 | .07 | .047 | .15 | .15 | .047 | .7 |
| Fold enrichment, mean ± SE | 79.5 ± 39.2 | 10.7 ± 2.2 | 83.3 ± 38.0 | 1.2 ± 0.1 | 3.8 ± 1.2 | NA | NA | 2.7 ± 1.1 | NA |
Freshly isolated BLT1+ T cells from blood were analyzed for coexpression of chemokine receptors by flow cytometry. These data are from 5 to 6 independent experiments. NA indicates not applicable.