BMT from NIMA-exposed donor maintained GVL activity
. | . | P815 cells, 2.5 × 104 . | . | P815 cells, 5.0 × 105 . | . | ||
|---|---|---|---|---|---|---|---|
| Donor . | Host . | MST, d . | SE . | MST, d . | SE . | ||
| BDF1 | BDF1 | 14.2 | 0.4 | 10.3 | 2.9 | ||
| NIMA-B6 | BDF1 | 51.2* | 2.6 | 48.0* | 3.1 | ||
| Control-B6 | BDF1 | 55.7* | 12.0 | 48.3* | 5.7 | ||
. | . | P815 cells, 2.5 × 104 . | . | P815 cells, 5.0 × 105 . | . | ||
|---|---|---|---|---|---|---|---|
| Donor . | Host . | MST, d . | SE . | MST, d . | SE . | ||
| BDF1 | BDF1 | 14.2 | 0.4 | 10.3 | 2.9 | ||
| NIMA-B6 | BDF1 | 51.2* | 2.6 | 48.0* | 3.1 | ||
| Control-B6 | BDF1 | 55.7* | 12.0 | 48.3* | 5.7 | ||
B6D2F1 mice were irradiated with 13 Gy TBI and received transplants with 5 × 106 TCD BM cells from a control B6 mouse and 2.5 × 104 P815 cells and 5 × 105 together with 2 × 106 T cells from either a NIMA donor or a control donor.
MST indicates mean survival time; SE, standard error.
P < .005 versus syngeneic controls