Correlation between ADAMTS13 levels and organ injury in patients with sepsis-induced DIC
. | ADAMTS13 activity less than 20%, n = 51 . | ADAMTS13 activity greater than 20%, n = 52 . | P . |
|---|---|---|---|
| Creatinine, mg/dL | 1.81 ± 1.70 | 0.95 ± 0.76 | < .01* |
| AST, IU/L | 106 ± 128 | 182 ± 290 | NS |
| ALT, IU/L | 72 ± 109 | 122 ± 160 | NS |
| Bilirubin, mg/dL | 2.70 ± 3.13 | 2.20 ± 2.53 | NS |
| Albumin, g/dL | 2.3 ± 0.4 | 2.9 ± 0.7 | < .05* |
| CRP, mg/dL | 13.50 ± 10.51 | 6.90 ± 8.61 | < .01* |
| Organ injury, no. (%) | |||
| Renal injury | 21 (41.2) | 8 (15.4) | < .05† |
| Liver injury | 40 (78.4) | 38 (73.1) | NS |
. | ADAMTS13 activity less than 20%, n = 51 . | ADAMTS13 activity greater than 20%, n = 52 . | P . |
|---|---|---|---|
| Creatinine, mg/dL | 1.81 ± 1.70 | 0.95 ± 0.76 | < .01* |
| AST, IU/L | 106 ± 128 | 182 ± 290 | NS |
| ALT, IU/L | 72 ± 109 | 122 ± 160 | NS |
| Bilirubin, mg/dL | 2.70 ± 3.13 | 2.20 ± 2.53 | NS |
| Albumin, g/dL | 2.3 ± 0.4 | 2.9 ± 0.7 | < .05* |
| CRP, mg/dL | 13.50 ± 10.51 | 6.90 ± 8.61 | < .01* |
| Organ injury, no. (%) | |||
| Renal injury | 21 (41.2) | 8 (15.4) | < .05† |
| Liver injury | 40 (78.4) | 38 (73.1) | NS |
Values for all categories except organ injury are mean ± SD. Renal injury: serum creatinine greater than 1.2 mg/dL.
Liver injury: elevation of bilirubin (> 2.0 mg/dL), AST (> 40 IU/L), or ALT (> 40 IU/L).
To convert creatinine from milligrams per deciliter to micromoles per liter, multiply milligrams per deciliter by 88.4.
To convert bilirubin from milligrams per deciliter to micromoles per liter, multiply milligrams per deciliter by 17.1.
To convert albumin from grams per deciliter to grams per liter, multiply grams per deciliter by 10.
To convert CRP from milligrams per deciliter to milligrams per liter, multiply milligrams per deciliter by 10.
NS indicates not significant.
Statistically significant (Welch t test).
Statistically significant (Fisher exact probability test).