Apoptosis parameters in patient groups with good and poor response to treatment
. | cdtotal, % . | . | . | actotal, % . | . | . | cctotal, % . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter . | Mean . | SEM . | P . | Mean . | SEM . | P . | Mean . | SEM . | P . | ||||||
| Day 8, prednisone response | .991 | .929 | .247 | ||||||||||||
| Good | 34.6 | 2.4 | 24.3 | 2.0 | 28.4 | 2.3 | |||||||||
| Poor | 34.5 | 8.0 | 24.8 | 5.1 | 36.6 | 6.4 | |||||||||
| Day 15, blast cell persistence | .126 | .013* | .478 | ||||||||||||
| Less than 5% | 36.3 | 3.3 | 27.8 | 2.6 | 28.3 | 3.1 | |||||||||
| More than 5% | 28.4 | 3.9 | 18.2 | 2.7 | 31.9 | 4.0 | |||||||||
| Day 33, remission | .918 | .590 | .555 | ||||||||||||
| Yes | 34.5 | 2.3 | 24.7 | 1.9 | 29.3 | 2.3 | |||||||||
| No | 36.3 | 15.7 | 18.8 | 9.8 | 35.8 | 9.6 | |||||||||
| Relapse | .435 | .010* | .539 | ||||||||||||
| No | 35.5 | 2.7 | 27.1 | 2.0 | 28.9 | 2.5 | |||||||||
| Yes | 31.2 | 4.8 | 14.7 | 3.9 | 32.2 | 4.6 | |||||||||
. | cdtotal, % . | . | . | actotal, % . | . | . | cctotal, % . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter . | Mean . | SEM . | P . | Mean . | SEM . | P . | Mean . | SEM . | P . | ||||||
| Day 8, prednisone response | .991 | .929 | .247 | ||||||||||||
| Good | 34.6 | 2.4 | 24.3 | 2.0 | 28.4 | 2.3 | |||||||||
| Poor | 34.5 | 8.0 | 24.8 | 5.1 | 36.6 | 6.4 | |||||||||
| Day 15, blast cell persistence | .126 | .013* | .478 | ||||||||||||
| Less than 5% | 36.3 | 3.3 | 27.8 | 2.6 | 28.3 | 3.1 | |||||||||
| More than 5% | 28.4 | 3.9 | 18.2 | 2.7 | 31.9 | 4.0 | |||||||||
| Day 33, remission | .918 | .590 | .555 | ||||||||||||
| Yes | 34.5 | 2.3 | 24.7 | 1.9 | 29.3 | 2.3 | |||||||||
| No | 36.3 | 15.7 | 18.8 | 9.8 | 35.8 | 9.6 | |||||||||
| Relapse | .435 | .010* | .539 | ||||||||||||
| No | 35.5 | 2.7 | 27.1 | 2.0 | 28.9 | 2.5 | |||||||||
| Yes | 31.2 | 4.8 | 14.7 | 3.9 | 32.2 | 4.6 | |||||||||
On day 8, for patients with good prednisone response, n = 66; with poor response, n = 12. On day 15, for patients with less than 5% blast cell persistence, n = 36; for more than 5% persistence, n = 27. On day 33, for patients in remission, n = 74; for patients not in remission, n = 4. For patients not experiencing relapse, n = 61; for those with relapse, n = 17.
cdtotal indicates cell death; actotal, activated caspase-3; cctotal, cytochrome c release; P, significance (t test); and SEM, standard error of the mean.
Difference is significant (2-tailed).