Effect of 8-SPT (adenosine receptor antagonist), ascorbate, and glutathione (GSH) on the potentiation of nitrite-dependent vasodilation by deoxygenated RBCs
. | EC20 for nitrite-dependent vasodilation, μM . |
|---|---|
| RBCs | 5.4 ± 1.8 |
| RBCs + 100 μM glutathione | 7.1 ± 2.1 |
| RBCs + 100 μM ascorbate | 6.3 ± 0.3 |
| RBCs + 15 μM 8-SPT | 5.3 ± 0.6 |
. | EC20 for nitrite-dependent vasodilation, μM . |
|---|---|
| RBCs | 5.4 ± 1.8 |
| RBCs + 100 μM glutathione | 7.1 ± 2.1 |
| RBCs + 100 μM ascorbate | 6.3 ± 0.3 |
| RBCs + 15 μM 8-SPT | 5.3 ± 0.6 |
Experiments were performed with rat RBCs at 25 mmHg. Data represent mean ± SEM (n = 3). Final concentration of RBCs was 0.3% HCT.