Patterns of mutations in the intron downstream of ther rearranged VHDHJH4 joints of GC B cells
. | M17+/+, % mutations . | . | . | . | . | M17-/-, % mutations . | . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Organ and base from which mutation occurred . | Base to which mutation occurred . | . | . | . | . | Base to which mutation occurred . | . | . | . | . | ||||||
| . | A . | G . | C . | T . | Total . | A . | G . | C . | T . | Total . | ||||||
| Spleen | ||||||||||||||||
| A | NA | 25 | 8 | 12 | 45 | NA | 14 | 10 | 6 | 30 | ||||||
| G | 14 | NA | 9 | 1 | 24 | 13 | NA | 3 | 3 | 19 | ||||||
| C | 1 | 5 | NA | 5 | 11 | 1 | 2 | NA | 12 | 15 | ||||||
| T | 3 | 2 | 16 | NA | 21 | 9 | 9 | 19 | NA | 37 | ||||||
| Peyer patches | ||||||||||||||||
| A | NA | 25 | 7 | 11 | 43 | NA | 20 | 11 | 15 | 46 | ||||||
| G | 16 | NA | 6 | 3 | 25 | 12 | NA | 6 | 5 | 23 | ||||||
| C | 1 | 1 | NA | 6 | 8 | 1 | 1 | NA | 11 | 13 | ||||||
| T | 5 | 9 | 9 | NA | 23 | 6 | 3 | 10 | NA | 19 | ||||||
. | M17+/+, % mutations . | . | . | . | . | M17-/-, % mutations . | . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Organ and base from which mutation occurred . | Base to which mutation occurred . | . | . | . | . | Base to which mutation occurred . | . | . | . | . | ||||||
| . | A . | G . | C . | T . | Total . | A . | G . | C . | T . | Total . | ||||||
| Spleen | ||||||||||||||||
| A | NA | 25 | 8 | 12 | 45 | NA | 14 | 10 | 6 | 30 | ||||||
| G | 14 | NA | 9 | 1 | 24 | 13 | NA | 3 | 3 | 19 | ||||||
| C | 1 | 5 | NA | 5 | 11 | 1 | 2 | NA | 12 | 15 | ||||||
| T | 3 | 2 | 16 | NA | 21 | 9 | 9 | 19 | NA | 37 | ||||||
| Peyer patches | ||||||||||||||||
| A | NA | 25 | 7 | 11 | 43 | NA | 20 | 11 | 15 | 46 | ||||||
| G | 16 | NA | 6 | 3 | 25 | 12 | NA | 6 | 5 | 23 | ||||||
| C | 1 | 1 | NA | 6 | 8 | 1 | 1 | NA | 11 | 13 | ||||||
| T | 5 | 9 | 9 | NA | 23 | 6 | 3 | 10 | NA | 19 | ||||||
For M17+/+ spleens, number of mutations (n) = 102 and the ratio of transitions to transversions (Tr/Tv) = 1.5; for M17-/- spleens, n = 117 and Tr/Tv = 1.3; for M17+/+ Peyer patches, n = 196 and Tr/Tv = 1.3; for M17-/- Peyer patches, n = 213 and Tr/Tv = 1.1. NA indicates not applicable.