Mutations A to F refer to those originally identified in Falini et al.⁸  Mutations from E• to H• refer to those identified in childhood AML cases in Cazzaniga et al.³⁰  Mutations G_m to Q_m refer to those identified in Schnittger et al²³  in protocol 99 of the German AML cooperative group; mutations 1, 3, 4, 6, 7, 12, 13, 10 and 14 according to Döhner et al²² ; mutations G^†, I^†, H^† and J^† according to Suzuki et al³¹ ; mutation I^Δ according to Verhaak et al.²⁴  Lowercase letters in nucleotide sequences indicate wild-type sequence residues; capital letters, mutated nucleotides. Underlined text indicates leucine-rich NES motif; italics, tryptophan (W) residues.

WT indicates wild type; L, leucin; V, valine; F, phenylalanine; M, methionine; C, cysteine.

NM 002520.