Gene-expression profiles in CD34 cells treated with IFN-γ in vitro compared with expression profiles in bone marrow failure states
. | . | . | MDS . | . | . | . | PNH . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|
| GenBank no. . | Gene name . | IFN-γ treated . | –7 . | +8 . | AA . | GPI-D . | GPI-N . | GPI-N vs GPI-D . | ||
| Similarly altered genes | ||||||||||
| Apoptosis genes | ||||||||||
| X63717† | FAS* | ↑4 | – | – | ↑ | – | ↑ | ↑ | ||
| U37518† | TRAIL* | ↑20 | ↑ | – | ↑ | – | ↑ | – | ||
| X98175 | CASP8* | ↑20 | ↑ | – | – | – | – | – | ||
| M92357†† | B94, TNFα-induced protein 2 | ↑20 | ↑ | ↑ | ↑ | – | – | – | ||
| Y16961 | Tumor protein, 63 kDa, with strong homology to p53 | ↑20 | ↑ | ↑ | – | – | – | – | ||
| U43746 | Breast cancer 2, early onset | ↑20 | ↑ | – | – | – | – | – | ||
| X04434 | Insulin-like growth factor 1 receptor | ↑20 | – | ↑ | – | – | – | – | ||
| M31165† | TNFα-induced protein 6 | ↑20 | – | – | ↑ | – | – | – | ||
| AF061034† | Optineurin | ↑20 | – | – | ↑ | – | – | – | ||
| AF005775 | CFLAR | ↑20 | – | – | ↑ | – | ↑ | – | ||
| Cytokines/chemokines and receptors | ||||||||||
| X02910 | TNF | ↑20 | – | – | ↑ | – | ↑ | ↑ | ||
| U00672 | IL10RA* | ↑20 | – | ↑ | ↑ | – | – | – | ||
| M21121 | CCL5* | ↑20 | – | – | ↑ | – | ↑ | ↑ | ||
| Y16645† | CCL8* | ↑20 | – | ↑ | – | – | ↑ | ↑ | ||
| AF030514† | CXCL11* | ↑20 | – | – | – | – | ↑ | ↑ | ||
| X72755† | CXCL9* | ↑4, ↑40 | – | – | – | – | ↑ | ↑ | ||
| X02530† | CXCL10* | ↑4, ↑40 | – | – | – | – | – | ↑ | ||
| Cell adhesion | ||||||||||
| M30257 | VCAM1 | ↑20 | – | ↑ | – | – | – | – | ||
| U88964† | IS320 | ↑20 | – | – | ↑ | – | ↑ | – | ||
| M63193† | EGF1 | ↑20 | – | – | ↑ | – | – | – | ||
| M73255† | VCAM1 | ↑20 | – | – | ↑ | – | – | – | ||
| Cell growth and maintenance | ||||||||||
| AF044309 | Syntaxin 11 | ↑20 | – | – | – | – | ↑ | – | ||
| X57522† | Transporter 1 (MDR/TAP)* | ↑20 | – | – | – | – | ↑ | – | ||
| M77016 | Tropomodulin 1 | ↑20 | – | – | – | ↑ | – | – | ||
| U20982 | Insulin-like growth factor-binding protein 4 | ↑20 | – | – | – | – | – | ↑ | ||
| J04164† | IFM1 (9-27)* | ↑20, ↑20 | – | – | ↑ | – | ↑ | – | ||
| X59892† | Tryptophanyl-tRNA synthetase* | ↑20, ↑20 | – | – | – | – | ↑ | ↑ | ||
| Signal transduction | ||||||||||
| U02020† | Pre–B-cell colony-enhancing factor 1 | ↑4 | – | – | ↑ | – | ↑ | – | ||
| D10923 | Putative chemokine receptor | ↑4 | – | – | – | – | ↑ | – | ||
| M97935† | STAT1* | ↑20 | – | – | ↑ | – | – | ↑ | ||
| Immune response | ||||||||||
| X16354† | Carcinoembryonic antigen-related cell-adhesion molecule 1* | ↑4 | – | – | ↑ | – | – | – | ||
| M55543† | GBP2 | ↑20 | – | – | ↑ | – | ↑ | ↑ | ||
| M55542† | GBP1 | ↑20 | – | – | – | – | ↑ | ↑ | ||
| M13755† | GIP2 | ↑4, ↑20 | – | – | – | – | ↑ | – | ||
| Transcription factor | ||||||||||
| L19871† | Activating transcription factor 3* | ↑4 | – | – | – | – | ↑ | – | ||
| Contradictory expression genes | ||||||||||
| U64198 | IL12RB2* | ↑4 | – | – | ↓ | ↓ | – | – | ||
| M36820† | CXCL2* | ↓4 | – | – | ↑ | – | ↑ | ↑ | ||
| M36821† | CXCL3* | ↓4 | – | – | ↑ | – | ↑ | ↑ | ||
| AF043129 | IL-7R | ↓4, ↓20 | – | ↑ | ↑ | – | ↑ | ↑ | ||
| M27492 | IL-1R1 | ↓4, ↓20 | – | – | ↑ | – | – | – | ||
. | . | . | MDS . | . | . | . | PNH . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|
| GenBank no. . | Gene name . | IFN-γ treated . | –7 . | +8 . | AA . | GPI-D . | GPI-N . | GPI-N vs GPI-D . | ||
| Similarly altered genes | ||||||||||
| Apoptosis genes | ||||||||||
| X63717† | FAS* | ↑4 | – | – | ↑ | – | ↑ | ↑ | ||
| U37518† | TRAIL* | ↑20 | ↑ | – | ↑ | – | ↑ | – | ||
| X98175 | CASP8* | ↑20 | ↑ | – | – | – | – | – | ||
| M92357†† | B94, TNFα-induced protein 2 | ↑20 | ↑ | ↑ | ↑ | – | – | – | ||
| Y16961 | Tumor protein, 63 kDa, with strong homology to p53 | ↑20 | ↑ | ↑ | – | – | – | – | ||
| U43746 | Breast cancer 2, early onset | ↑20 | ↑ | – | – | – | – | – | ||
| X04434 | Insulin-like growth factor 1 receptor | ↑20 | – | ↑ | – | – | – | – | ||
| M31165† | TNFα-induced protein 6 | ↑20 | – | – | ↑ | – | – | – | ||
| AF061034† | Optineurin | ↑20 | – | – | ↑ | – | – | – | ||
| AF005775 | CFLAR | ↑20 | – | – | ↑ | – | ↑ | – | ||
| Cytokines/chemokines and receptors | ||||||||||
| X02910 | TNF | ↑20 | – | – | ↑ | – | ↑ | ↑ | ||
| U00672 | IL10RA* | ↑20 | – | ↑ | ↑ | – | – | – | ||
| M21121 | CCL5* | ↑20 | – | – | ↑ | – | ↑ | ↑ | ||
| Y16645† | CCL8* | ↑20 | – | ↑ | – | – | ↑ | ↑ | ||
| AF030514† | CXCL11* | ↑20 | – | – | – | – | ↑ | ↑ | ||
| X72755† | CXCL9* | ↑4, ↑40 | – | – | – | – | ↑ | ↑ | ||
| X02530† | CXCL10* | ↑4, ↑40 | – | – | – | – | – | ↑ | ||
| Cell adhesion | ||||||||||
| M30257 | VCAM1 | ↑20 | – | ↑ | – | – | – | – | ||
| U88964† | IS320 | ↑20 | – | – | ↑ | – | ↑ | – | ||
| M63193† | EGF1 | ↑20 | – | – | ↑ | – | – | – | ||
| M73255† | VCAM1 | ↑20 | – | – | ↑ | – | – | – | ||
| Cell growth and maintenance | ||||||||||
| AF044309 | Syntaxin 11 | ↑20 | – | – | – | – | ↑ | – | ||
| X57522† | Transporter 1 (MDR/TAP)* | ↑20 | – | – | – | – | ↑ | – | ||
| M77016 | Tropomodulin 1 | ↑20 | – | – | – | ↑ | – | – | ||
| U20982 | Insulin-like growth factor-binding protein 4 | ↑20 | – | – | – | – | – | ↑ | ||
| J04164† | IFM1 (9-27)* | ↑20, ↑20 | – | – | ↑ | – | ↑ | – | ||
| X59892† | Tryptophanyl-tRNA synthetase* | ↑20, ↑20 | – | – | – | – | ↑ | ↑ | ||
| Signal transduction | ||||||||||
| U02020† | Pre–B-cell colony-enhancing factor 1 | ↑4 | – | – | ↑ | – | ↑ | – | ||
| D10923 | Putative chemokine receptor | ↑4 | – | – | – | – | ↑ | – | ||
| M97935† | STAT1* | ↑20 | – | – | ↑ | – | – | ↑ | ||
| Immune response | ||||||||||
| X16354† | Carcinoembryonic antigen-related cell-adhesion molecule 1* | ↑4 | – | – | ↑ | – | – | – | ||
| M55543† | GBP2 | ↑20 | – | – | ↑ | – | ↑ | ↑ | ||
| M55542† | GBP1 | ↑20 | – | – | – | – | ↑ | ↑ | ||
| M13755† | GIP2 | ↑4, ↑20 | – | – | – | – | ↑ | – | ||
| Transcription factor | ||||||||||
| L19871† | Activating transcription factor 3* | ↑4 | – | – | – | – | ↑ | – | ||
| Contradictory expression genes | ||||||||||
| U64198 | IL12RB2* | ↑4 | – | – | ↓ | ↓ | – | – | ||
| M36820† | CXCL2* | ↓4 | – | – | ↑ | – | ↑ | ↑ | ||
| M36821† | CXCL3* | ↓4 | – | – | ↑ | – | ↑ | ↑ | ||
| AF043129 | IL-7R | ↓4, ↓20 | – | ↑ | ↑ | – | ↑ | ↑ | ||
| M27492 | IL-1R1 | ↓4, ↓20 | – | – | ↑ | – | – | – | ||