Table 1. Characterization of CCR5 –/–... | American Society of Hematology

Table 1.

Characterization of CCR5^–/– apoE^–/– and CCR1^–/– apoE^–/– mice

	CCR5^+/+ apoE^-/-	CCR5^-/- apoE^-/-	P	CCR1^+/+ apoE^-/-	CCR1^-/- apoE^-/-	P
Neointimal area, μm²	17 894 ± 2 934	6 631 ± 1 026	.005	10 414 ± 1 385	10 591 ± 1 886	NS
% EEL area	32.3 ± 2.6	13.7 ± 2.2	< .001	28.0 ± 2.9	27.9 ± 2.5	NS
Medial area, μm²	12 689 ± 1 162	11 696 ± 474	NS	14 608 ± 2 726	13 820 ± 1 487	NS
% EEL area	26.0 ± 3.3	21.5 ± 1.8	NS	25.0 ± 2.9	23.5 ± 2.7	NS
Macrophage content, % neointimal area	23.2 ± 7.0	5.8 ± 3.2	.035	11.0 ± 7.6	13.7 ± 5.4	NS
SMC content, % neointimal area	27.5 ± 3.7	61.7 ± 6.0	.003	21.8 ± 3.7	37.5 ± 7.1	NS
T-cell content, % neointimal area	15.3 ± 0.6	2.4 ± 1.0	< .001	10.3 ± 2.0	6.4 ± 1.4	NS
IFN-γ content, % neointimal area	2.0 ± 1.2	1.2 ± 1.2	NS	0.3 ± 0.3	6.7 ± 2.0	.037
IL-10 content, % neointimal area	13.6 ± 0.8	29.3 ± 4.1	.020	10.3 ± 3.5	11.8 ± 2.4	NS
CD4⁺/IFN-γ⁺ cells, % splenocytes	2.30 ± 0.12	1.53 ± 0.20	.030	2.60 ± 0.30	2.84 ± 0.19	NS
CD4⁺/IL-10⁺ cells, % splenocytes	0.58 ± 0.07	1.19 ± 0.18	.036	0.86 ± 0.06	0.50 ± 0.06	.008
Th1/Th2 index, IFN-γ⁺/IL-10⁺	4.0	1.3	—	3.1	5.7	—

	CCR5^+/+ apoE^-/-	CCR5^-/- apoE^-/-	P	CCR1^+/+ apoE^-/-	CCR1^-/- apoE^-/-	P
Neointimal area, μm²	17 894 ± 2 934	6 631 ± 1 026	.005	10 414 ± 1 385	10 591 ± 1 886	NS
% EEL area	32.3 ± 2.6	13.7 ± 2.2	< .001	28.0 ± 2.9	27.9 ± 2.5	NS
Medial area, μm²	12 689 ± 1 162	11 696 ± 474	NS	14 608 ± 2 726	13 820 ± 1 487	NS
% EEL area	26.0 ± 3.3	21.5 ± 1.8	NS	25.0 ± 2.9	23.5 ± 2.7	NS
Macrophage content, % neointimal area	23.2 ± 7.0	5.8 ± 3.2	.035	11.0 ± 7.6	13.7 ± 5.4	NS
SMC content, % neointimal area	27.5 ± 3.7	61.7 ± 6.0	.003	21.8 ± 3.7	37.5 ± 7.1	NS
T-cell content, % neointimal area	15.3 ± 0.6	2.4 ± 1.0	< .001	10.3 ± 2.0	6.4 ± 1.4	NS
IFN-γ content, % neointimal area	2.0 ± 1.2	1.2 ± 1.2	NS	0.3 ± 0.3	6.7 ± 2.0	.037
IL-10 content, % neointimal area	13.6 ± 0.8	29.3 ± 4.1	.020	10.3 ± 3.5	11.8 ± 2.4	NS
CD4⁺/IFN-γ⁺ cells, % splenocytes	2.30 ± 0.12	1.53 ± 0.20	.030	2.60 ± 0.30	2.84 ± 0.19	NS
CD4⁺/IL-10⁺ cells, % splenocytes	0.58 ± 0.07	1.19 ± 0.18	.036	0.86 ± 0.06	0.50 ± 0.06	.008
Th1/Th2 index, IFN-γ⁺/IL-10⁺	4.0	1.3	—	3.1	5.7	—

Data represent mean ± SEM.

EEL indicates external elastic lamina; NS, not significant;—, not applicable.