Table 1. IC50 values of panPKC LMWI on... | American Society of Hematology

Table 1.

IC50 values of panPKC LMWI on isolated PKC isotypes in kinase assays and established controls as Ro-31-8220, GF109203X

Substance	PKC-θ IC50, μM	PKC-α IC50, μM	PKC-β IC50, μM	PKC-δ IC50, μM	PKC-η IC50, μM	PKC-ϵ IC50, μM	PKC-ι IC50, μM	PKC-ζ IC50, μM
panPKC LMWI	0.00113	0.00337	0.00954	0.00252	0.00995	0.00308	>1	>1
Ro-31-8220	0.0049	0.0025	0.0069	0.0059	0.0064	0.0047	>1	>1
GF109203X	0.0101	0.0033	0.0061	0.0795	0.0352	0.0089	>50	>100

Substance	PKC-θ IC50, μM	PKC-α IC50, μM	PKC-β IC50, μM	PKC-δ IC50, μM	PKC-η IC50, μM	PKC-ϵ IC50, μM	PKC-ι IC50, μM	PKC-ζ IC50, μM
panPKC LMWI	0.00113	0.00337	0.00954	0.00252	0.00995	0.00308	>1	>1
Ro-31-8220	0.0049	0.0025	0.0069	0.0059	0.0064	0.0047	>1	>1
GF109203X	0.0101	0.0033	0.0061	0.0795	0.0352	0.0089	>50	>100