Table 1.

ALL: differentially expressed genes between high versus low ZAP70 cases with no known molecular aberrations

Gene symbol
Probe set
Locuslink ID
P
GO process
Chromosomal location
ZAP70  1498_at   7535   <.001   Immune response   2q12  
AP3D1  36173_r_at   8943   <.001   Intracellular protein transport   19p13.3  
SEMA6A  36275_at   57556   <.001   Cytoskeleton organization and biogenesis   5q23.1  
CSPG2  38112_g_at   1462   <.001   Development   5q14.3  
ITGA5  39753_at   3678   <.001   Integrin-mediated signaling pathway   12q11-q13  
CRADD  1211_s_at   8738   <.001   Induction of apoptosis via death domain receptors   12q21.33-q23.1  
AGPS  39225_at   8540   <.001   Lipid metabolism   2q31  
AP3D1  36172_s_at   8943   <.001   Intracellular protein transport   19p13.3  
LOC90410  41561_s_at   55977   <.001   Unknown   17q11.2  
LAT  40688_at   27040   <.001   Regulation of T-cell activation   16p11.2  
ACVR2  35162_s_at   92   .001   –   2q22.2-q23.3  
SOCS1  41593_at   8651   .001   Intracellular signaling cascade   16p13.13  
CASP10  1326_at   843   .001   Induction of apoptosis   2q33-q34  
XPC  35647_at   7508   .001   Nucleotide-excision repair   3p25  
TNFRSF1B  33813_at   7133   .001   Apoptosis   Ip36.3-p36.2  
TCRB  1105_s_at   6957   .001   Immune response   7q34  
HPS1  38467_at   3257   .001   –   10q23.1-q23.3  
PTE1  36841_at   10005   .001   Acyl-coA metabolism   20q12-q13.1  
TNFRSF1B  1583_at   7133   .001   Apoptosis   1p36.3-p36.2  
CASP8  33774_at   841   .001   Apoptosis   2q33-q34  
TR1P6  39341_at   7205   .001   –   7q22  
PCSK7  34361_at   9159   .001   Proteolysis and peptidolysis   11q23-q24  
LCK  33238_at   3932   .001   Intracellular signaling cascade   1p34.3  
CASP8  33775_s_at   841   .001   Induction of apoptosis   2q33-q34  
KLRB1  35449_at   3820   .002   Cell surface receptor linked signaling   12p13.1  
LRRC15  34778_at   131578   .002   –   3q29  
PHC2  36960_at   1912   .002   –   1p34.3  
MYBL1  160043_at   4603   .002   Regulation of transcription, DNA dependent   8q22  
CKMT2  37592_at   1160   .002   Muscle contraction   5q13.3  
RQCD1  722_at   9125   .002   Sex differentiation   2q35  
RRAD  1776_at   6236   .002   GTPase activity   16q22  
CNOT8  41361_at   9337   .002   Negative regulation of cell proliferation   5q31-33  
OR511  31428_at   10798   .002   G-protein-coupled receptor protein signaling   11q11  
GPR56  35769_at   9289   .002   Cell-cell signaling   16q13  
EPM2AIP1  35209_at   9852   .002   –   3p22.1  
GRIN1  37134_f_at   2902   .002   Glutamate-signaling pathway   9q34.3  
CTGF  36638_at   1490   .002   Epidermis development   6q23.1  
PDE9A  33709_at   5152   .003   Signal transduction   21q22.3  
IL27RA  37844_at   9466   .003   –   19p13.11  
KIAA0542  36545_s_at   9814   .003   –   22q12.2  
FGR  1780_at   2268   .003   Protein amino acid phosphorylation  1p36.2-p36.1  
SPINK1  38582_at   6690   .003   –   5q32  
FLJ10803  37610_at   55744   .003   –   7p13  
E2F4  38706_at   1874   .003   Regulation of cell cycle   16q21-q22  
FOXM1  41324_g_at   2305   .003   Transcription from RNA polymerase II promoter   12p13  
CTSW  40718_at   1521   .003   Immune response   11q13.1  
TP53BP1  1711_at   7158   .003   Transcription   15q15-q21  
TTN  40795_at   7273   .003   Striated muscle contraction   2q31  
BAIAP2  37760_at   10458   .003   Insulin receptor signaling pathway   17q25  
ANXA11  36637_at   311   .003   Immune response   10q23  
IGJ  37006_at   10569   .003   Immune response   4q21  
PFAAP5  1532_g_at   10443   .004   –   13q12-q13  
HPN  37639_at   3249   .004   Proteolysis and peptidolysis   19q11-q13.2  
CD200  37716_at   4345   .004   –   3q12-q13  
TCF20  33795_at   6942   .004   Regulation of transcription, DNA dependent   22q13.3  
BRF1  141_s_at   2972   .004   Transcription initiation from RNA polymerase III   14q  
BBC3  1700_at   27113   .004   Apoptosis   19q13.3-q13.4  
KIAA0194  34221_at   22993   .004   Regulation of transcription, DNA dependent   5q33.1  
CDK9  387_at   1025   .004   Regulation of cell cycle   9q34.1  
CTNND1  40444_s_at   1500   .004   Cell-cell adhesion   11q11  
IL32  39119_s_at   9235   .004   Immune response   16p13.3  
DGKA  32716_at   1606   .004   Intracellular signaling cascade   12q13.3  
PBX3  32696_at   5090   .004   Regulation of transcription, DNA dependent   9q33-q34  
MLL4  38284_at   9757   .004   Regulation of transcription, DNA dependent   19q13.1  
SF3B3  32753_at   23450   .004   RNA splicing   16q22.1  
Unknown   34204_at   unknown   .004   Unknown   Unknown  
STK39  40966_at   27347   .004   Protein amino acid phosphorylation  2q24.3  
PIK4CA  40783_s_at   5297   .004   Phosphatidylinositol biosynthesis   22q11.21  
ATM  1863_s_at   472   .005   DNA repair   11q22-q23  
Unknown   38423_at   Unknown   .005   Unknown   17q21.2  
AIP  36586_at   9049   .005   Protein folding   11q13.3  
GAB1  1249_at   2549   .005   Cell proliferation   4q31.21  
SLC2A1  40507_at   6513   .005   Glucose transport   1p35-p31.3  
Unknown   32467_at   Unknown   .005   Unknown   Unknown  
PTPN18
 		 33453_at
 		 537
 		 .005
 		 Protein amino acid dephosphorylation
 		2q21.1
 
Gene symbol
Probe set
Locuslink ID
P
GO process
Chromosomal location
ZAP70  1498_at   7535   <.001   Immune response   2q12  
AP3D1  36173_r_at   8943   <.001   Intracellular protein transport   19p13.3  
SEMA6A  36275_at   57556   <.001   Cytoskeleton organization and biogenesis   5q23.1  
CSPG2  38112_g_at   1462   <.001   Development   5q14.3  
ITGA5  39753_at   3678   <.001   Integrin-mediated signaling pathway   12q11-q13  
CRADD  1211_s_at   8738   <.001   Induction of apoptosis via death domain receptors   12q21.33-q23.1  
AGPS  39225_at   8540   <.001   Lipid metabolism   2q31  
AP3D1  36172_s_at   8943   <.001   Intracellular protein transport   19p13.3  
LOC90410  41561_s_at   55977   <.001   Unknown   17q11.2  
LAT  40688_at   27040   <.001   Regulation of T-cell activation   16p11.2  
ACVR2  35162_s_at   92   .001   –   2q22.2-q23.3  
SOCS1  41593_at   8651   .001   Intracellular signaling cascade   16p13.13  
CASP10  1326_at   843   .001   Induction of apoptosis   2q33-q34  
XPC  35647_at   7508   .001   Nucleotide-excision repair   3p25  
TNFRSF1B  33813_at   7133   .001   Apoptosis   Ip36.3-p36.2  
TCRB  1105_s_at   6957   .001   Immune response   7q34  
HPS1  38467_at   3257   .001   –   10q23.1-q23.3  
PTE1  36841_at   10005   .001   Acyl-coA metabolism   20q12-q13.1  
TNFRSF1B  1583_at   7133   .001   Apoptosis   1p36.3-p36.2  
CASP8  33774_at   841   .001   Apoptosis   2q33-q34  
TR1P6  39341_at   7205   .001   –   7q22  
PCSK7  34361_at   9159   .001   Proteolysis and peptidolysis   11q23-q24  
LCK  33238_at   3932   .001   Intracellular signaling cascade   1p34.3  
CASP8  33775_s_at   841   .001   Induction of apoptosis   2q33-q34  
KLRB1  35449_at   3820   .002   Cell surface receptor linked signaling   12p13.1  
LRRC15  34778_at   131578   .002   –   3q29  
PHC2  36960_at   1912   .002   –   1p34.3  
MYBL1  160043_at   4603   .002   Regulation of transcription, DNA dependent   8q22  
CKMT2  37592_at   1160   .002   Muscle contraction   5q13.3  
RQCD1  722_at   9125   .002   Sex differentiation   2q35  
RRAD  1776_at   6236   .002   GTPase activity   16q22  
CNOT8  41361_at   9337   .002   Negative regulation of cell proliferation   5q31-33  
OR511  31428_at   10798   .002   G-protein-coupled receptor protein signaling   11q11  
GPR56  35769_at   9289   .002   Cell-cell signaling   16q13  
EPM2AIP1  35209_at   9852   .002   –   3p22.1  
GRIN1  37134_f_at   2902   .002   Glutamate-signaling pathway   9q34.3  
CTGF  36638_at   1490   .002   Epidermis development   6q23.1  
PDE9A  33709_at   5152   .003   Signal transduction   21q22.3  
IL27RA  37844_at   9466   .003   –   19p13.11  
KIAA0542  36545_s_at   9814   .003   –   22q12.2  
FGR  1780_at   2268   .003   Protein amino acid phosphorylation  1p36.2-p36.1  
SPINK1  38582_at   6690   .003   –   5q32  
FLJ10803  37610_at   55744   .003   –   7p13  
E2F4  38706_at   1874   .003   Regulation of cell cycle   16q21-q22  
FOXM1  41324_g_at   2305   .003   Transcription from RNA polymerase II promoter   12p13  
CTSW  40718_at   1521   .003   Immune response   11q13.1  
TP53BP1  1711_at   7158   .003   Transcription   15q15-q21  
TTN  40795_at   7273   .003   Striated muscle contraction   2q31  
BAIAP2  37760_at   10458   .003   Insulin receptor signaling pathway   17q25  
ANXA11  36637_at   311   .003   Immune response   10q23  
IGJ  37006_at   10569   .003   Immune response   4q21  
PFAAP5  1532_g_at   10443   .004   –   13q12-q13  
HPN  37639_at   3249   .004   Proteolysis and peptidolysis   19q11-q13.2  
CD200  37716_at   4345   .004   –   3q12-q13  
TCF20  33795_at   6942   .004   Regulation of transcription, DNA dependent   22q13.3  
BRF1  141_s_at   2972   .004   Transcription initiation from RNA polymerase III   14q  
BBC3  1700_at   27113   .004   Apoptosis   19q13.3-q13.4  
KIAA0194  34221_at   22993   .004   Regulation of transcription, DNA dependent   5q33.1  
CDK9  387_at   1025   .004   Regulation of cell cycle   9q34.1  
CTNND1  40444_s_at   1500   .004   Cell-cell adhesion   11q11  
IL32  39119_s_at   9235   .004   Immune response   16p13.3  
DGKA  32716_at   1606   .004   Intracellular signaling cascade   12q13.3  
PBX3  32696_at   5090   .004   Regulation of transcription, DNA dependent   9q33-q34  
MLL4  38284_at   9757   .004   Regulation of transcription, DNA dependent   19q13.1  
SF3B3  32753_at   23450   .004   RNA splicing   16q22.1  
Unknown   34204_at   unknown   .004   Unknown   Unknown  
STK39  40966_at   27347   .004   Protein amino acid phosphorylation  2q24.3  
PIK4CA  40783_s_at   5297   .004   Phosphatidylinositol biosynthesis   22q11.21  
ATM  1863_s_at   472   .005   DNA repair   11q22-q23  
Unknown   38423_at   Unknown   .005   Unknown   17q21.2  
AIP  36586_at   9049   .005   Protein folding   11q13.3  
GAB1  1249_at   2549   .005   Cell proliferation   4q31.21  
SLC2A1  40507_at   6513   .005   Glucose transport   1p35-p31.3  
Unknown   32467_at   Unknown   .005   Unknown   Unknown  
PTPN18
 		 33453_at
 		 537
 		 .005
 		 Protein amino acid dephosphorylation
 		2q21.1
 

Genes are rank ordered according to nominal P values. All genes have high expression, with the exception of AIP. GO indicates gene ontology; –, not recorded.

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