Patient characteristics for XPD751AA versus 751AC versus 751CC genotypes
. | . | . | . | P . | . | . | ||
|---|---|---|---|---|---|---|---|---|
| Characteristic . | AA; N = 193 . | AC; N = 202 . | CC; N = 61 . | AA vs AC . | AC vs CC . | AA vs CC . | ||
| Age, y, median (range) | 10.2 (0.15-19.5) | 9.6 (0.01-19.8) | 11.0 (0.13-20.9) | .43 | .57 | .98 | ||
| WBC count, × 109/L, median (range) | 22.8 (1-373.3) | 18.65 (1-860) | 18.8 (0.3-684) | .36 | .53 | .22 | ||
| Bone marrow blasts, %, median (range) | 70.5 (0-100) | 70 (1-100) | 67 (15-98) | .73 | .65 | .48 | ||
| Study, no. (%) | .30 | .47 | .09 | |||||
| CCG-2941 | 11 (6) | 18 (9) | 8 (13) | |||||
| CCG-2961 | 182 (94) | 184 (91) | 53 (87) | |||||
| Sex, no. (%) | .43 | .41 | .84 | |||||
| Male | 109 (56) | 105 (52) | 36 (59) | |||||
| Female | 84 (44) | 97 (48) | 25 (41) | |||||
| Race, no. (%) | ||||||||
| White | 116 (60) | 142 (70) | 55 (90) | .05 | < .01 | < .001 | ||
| Black | 20 (10) | 18 (9) | 0 (0) | .74 | .02 | .01 | ||
| Hispanic | 40 (21) | 26 (13) | 5 (8) | .05 | .44 | .04 | ||
| Asian | 7 (4) | 7 (3) | 0 (0) | .86 | .36 | .20 | ||
| Other | 9 (5) | 9 (4) | 1 (2) | .90 | .46 | .46 | ||
| Unknown | 1 (–) | 0 (–) | 0 (–) | – | – | – | ||
| FAB, no. (%) | ||||||||
| M0 | 17 (9) | 7 (3) | 2 (3) | .04 | > .99 | .26 | ||
| M1 | 30 (16) | 31 (15) | 9 (15) | .95 | .93 | .97 | ||
| M2 | 61 (32) | 53 (26) | 18 (30) | .27 | .73 | .86 | ||
| M4 | 39 (20) | 60 (30) | 19 (31) | .04 | .96 | .11 | ||
| M5 | 31 (16) | 37 (18) | 9 (15) | .66 | .65 | .95 | ||
| M6 | 5 (3) | 4 (2) | 1 (2) | .75 | > .99 | 1.00 | ||
| M7 | 5 (3) | 8 (4) | 3 (5) | .64 | .72 | .40 | ||
| Other | 4 (2) | 2 (1) | 0 (0) | .44 | > .99 | .58 | ||
| Unknown | 1 (–) | 0 (–) | 0 (–) | – | – | – | ||
| Cytogenetics, no. (%) | ||||||||
| Normal | 28 (23) | 27 (23) | 11 (31) | .94 | .48 | .51 | ||
| t(8;21) | 18 (15) | 18 (15) | 10 (28) | .90 | .14 | .13 | ||
| Abn 16 | 15 (13) | 10 (8) | 2 (6) | .42 | .73 | .36 | ||
| Abn 11 | 23 (19) | 26 (22) | 8 (22) | .67 | .84 | .87 | ||
| t(6;9) | 1 (1) | 3 (3) | 1 (3) | .37 | > .99 | .41 | ||
| –7/7q- | 6 (5) | 2 (2) | 0 (0) | .28 | > .99 | .34 | ||
| –5/5q- | 2 (2) | 2 (2) | 0 (0) | > .99 | > .99 | > .99 | ||
| +8 | 11 (9) | 7 (6) | 0 (0) | .48 | .20 | .07 | ||
| +21 | 2 (2) | 0 (0) | 0 (0) | .50 | > .99 | > .99 | ||
| Pseudodiploid | 10 (8) | 15 (13) | 3 (8) | .37 | .57 | > .99 | ||
| Hyperdiploid | 0 (0) | 7 (6) | 1 (3) | < .01 | .68 | .23 | ||
| Hypodiploid | 4 (3) | 1 (1) | 0 (0) | .37 | > .99 | .57 | ||
| Unknown | 73 (–) | 84 (–) | 25 (–) | – | – | – | ||
| CNS at on-study | 8 (4) | 10 (5) | 5 (8) | .89 | .35 | .31 | ||
| Chloroma at on-study | 15 (8) | 26 (13) | 8 (13) | .13 | .87 | .31 | ||
| Response at end of first course, no. (%) | ||||||||
| REM | 170 (90) | 165 (86) | 51 (84) | .30 | .81 | .26 | ||
| PD | 9 (5) | 15 (8) | 8 (13) | .31 | .32 | .04 | ||
| Die | 10 (5) | 12 (6) | 2 (3) | .86 | .53 | .74 | ||
| W/D or unevaluable | 4 (–) | 10 (–) | 0 (–) | – | – | – | ||
. | . | . | . | P . | . | . | ||
|---|---|---|---|---|---|---|---|---|
| Characteristic . | AA; N = 193 . | AC; N = 202 . | CC; N = 61 . | AA vs AC . | AC vs CC . | AA vs CC . | ||
| Age, y, median (range) | 10.2 (0.15-19.5) | 9.6 (0.01-19.8) | 11.0 (0.13-20.9) | .43 | .57 | .98 | ||
| WBC count, × 109/L, median (range) | 22.8 (1-373.3) | 18.65 (1-860) | 18.8 (0.3-684) | .36 | .53 | .22 | ||
| Bone marrow blasts, %, median (range) | 70.5 (0-100) | 70 (1-100) | 67 (15-98) | .73 | .65 | .48 | ||
| Study, no. (%) | .30 | .47 | .09 | |||||
| CCG-2941 | 11 (6) | 18 (9) | 8 (13) | |||||
| CCG-2961 | 182 (94) | 184 (91) | 53 (87) | |||||
| Sex, no. (%) | .43 | .41 | .84 | |||||
| Male | 109 (56) | 105 (52) | 36 (59) | |||||
| Female | 84 (44) | 97 (48) | 25 (41) | |||||
| Race, no. (%) | ||||||||
| White | 116 (60) | 142 (70) | 55 (90) | .05 | < .01 | < .001 | ||
| Black | 20 (10) | 18 (9) | 0 (0) | .74 | .02 | .01 | ||
| Hispanic | 40 (21) | 26 (13) | 5 (8) | .05 | .44 | .04 | ||
| Asian | 7 (4) | 7 (3) | 0 (0) | .86 | .36 | .20 | ||
| Other | 9 (5) | 9 (4) | 1 (2) | .90 | .46 | .46 | ||
| Unknown | 1 (–) | 0 (–) | 0 (–) | – | – | – | ||
| FAB, no. (%) | ||||||||
| M0 | 17 (9) | 7 (3) | 2 (3) | .04 | > .99 | .26 | ||
| M1 | 30 (16) | 31 (15) | 9 (15) | .95 | .93 | .97 | ||
| M2 | 61 (32) | 53 (26) | 18 (30) | .27 | .73 | .86 | ||
| M4 | 39 (20) | 60 (30) | 19 (31) | .04 | .96 | .11 | ||
| M5 | 31 (16) | 37 (18) | 9 (15) | .66 | .65 | .95 | ||
| M6 | 5 (3) | 4 (2) | 1 (2) | .75 | > .99 | 1.00 | ||
| M7 | 5 (3) | 8 (4) | 3 (5) | .64 | .72 | .40 | ||
| Other | 4 (2) | 2 (1) | 0 (0) | .44 | > .99 | .58 | ||
| Unknown | 1 (–) | 0 (–) | 0 (–) | – | – | – | ||
| Cytogenetics, no. (%) | ||||||||
| Normal | 28 (23) | 27 (23) | 11 (31) | .94 | .48 | .51 | ||
| t(8;21) | 18 (15) | 18 (15) | 10 (28) | .90 | .14 | .13 | ||
| Abn 16 | 15 (13) | 10 (8) | 2 (6) | .42 | .73 | .36 | ||
| Abn 11 | 23 (19) | 26 (22) | 8 (22) | .67 | .84 | .87 | ||
| t(6;9) | 1 (1) | 3 (3) | 1 (3) | .37 | > .99 | .41 | ||
| –7/7q- | 6 (5) | 2 (2) | 0 (0) | .28 | > .99 | .34 | ||
| –5/5q- | 2 (2) | 2 (2) | 0 (0) | > .99 | > .99 | > .99 | ||
| +8 | 11 (9) | 7 (6) | 0 (0) | .48 | .20 | .07 | ||
| +21 | 2 (2) | 0 (0) | 0 (0) | .50 | > .99 | > .99 | ||
| Pseudodiploid | 10 (8) | 15 (13) | 3 (8) | .37 | .57 | > .99 | ||
| Hyperdiploid | 0 (0) | 7 (6) | 1 (3) | < .01 | .68 | .23 | ||
| Hypodiploid | 4 (3) | 1 (1) | 0 (0) | .37 | > .99 | .57 | ||
| Unknown | 73 (–) | 84 (–) | 25 (–) | – | – | – | ||
| CNS at on-study | 8 (4) | 10 (5) | 5 (8) | .89 | .35 | .31 | ||
| Chloroma at on-study | 15 (8) | 26 (13) | 8 (13) | .13 | .87 | .31 | ||
| Response at end of first course, no. (%) | ||||||||
| REM | 170 (90) | 165 (86) | 51 (84) | .30 | .81 | .26 | ||
| PD | 9 (5) | 15 (8) | 8 (13) | .31 | .32 | .04 | ||
| Die | 10 (5) | 12 (6) | 2 (3) | .86 | .53 | .74 | ||
| W/D or unevaluable | 4 (–) | 10 (–) | 0 (–) | – | – | – | ||
– indicates not applicable.