Table 2.

Retrospective studies of ARL outcomes before and after HAART




HAART, no.

CR, %, HAART

Median OS, mo, HAART
Reference
Type and comments
No
Yes
No
Yes
P
No
Yes
P
Vaccher et al15   HAART: more neuropathy, anemia, fewer Ols   80   24   36   50   NS   7   NR   –  
Navarro et al16   CHOP regimen, all systemic ARL in this series; 2 yr OS (previous report): 60% vs 22%   54   39   39   60   .019   NR   NR   –  
Hoffmann et al17   CHOP regimen; HAART response associated with much better OS   142   61   48   71   .006   9   NR   –  
Besson et al  Mostly CHOP-like regimens; higher CD4 count at diagnosis after HAART   63   42   NR   NR    6.3   21.2   .004  
Gerard et al14 
 
Half of patients treated with intensive regimens; after HAART, fewer received dose-reduced regimens
 
131
 
115
 
55
 
69
 
.04
 
9.5
 
NR
 
< .001
 



HAART, no.

CR, %, HAART

Median OS, mo, HAART
Reference
Type and comments
No
Yes
No
Yes
P
No
Yes
P
Vaccher et al15   HAART: more neuropathy, anemia, fewer Ols   80   24   36   50   NS   7   NR   –  
Navarro et al16   CHOP regimen, all systemic ARL in this series; 2 yr OS (previous report): 60% vs 22%   54   39   39   60   .019   NR   NR   –  
Hoffmann et al17   CHOP regimen; HAART response associated with much better OS   142   61   48   71   .006   9   NR   –  
Besson et al  Mostly CHOP-like regimens; higher CD4 count at diagnosis after HAART   63   42   NR   NR    6.3   21.2   .004  
Gerard et al14 
 
Half of patients treated with intensive regimens; after HAART, fewer received dose-reduced regimens
 
131
 
115
 
55
 
69
 
.04
 
9.5
 
NR
 
< .001
 

NS indicates not significant; NR, not reported; and –, not calculated.

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