Table 1.

Studies of incidence of systemic/CNS or CNS-only ARL before and after HAART




Cases by HAART

Relative risk of systemic ARL before vs after HAART

Relative risk of CNS ARL before vs after HAART
Reference
Type and comments
Before
After
Grulich et al  Before HAART: 1990-94, 7.0 cases/1000 p-y, 94-96, 7.5; after HAART: 4.3, 96-98   190   23   0.6, P < .012   NR  
Kirk et al  Immunoblastic NHL 5-fold/Burkitt 6-fold decreased risk since HAART   125   97   0.44, P < .001   0.05  
Besson et al
 
French Hospital Database on HIV
 
415
 
285
 
0.50 (systemic only), P < .001
 
0.35, P < .001
 



Cases by HAART

Relative risk of systemic ARL before vs after HAART

Relative risk of CNS ARL before vs after HAART
Reference
Type and comments
Before
After
Grulich et al  Before HAART: 1990-94, 7.0 cases/1000 p-y, 94-96, 7.5; after HAART: 4.3, 96-98   190   23   0.6, P < .012   NR  
Kirk et al  Immunoblastic NHL 5-fold/Burkitt 6-fold decreased risk since HAART   125   97   0.44, P < .001   0.05  
Besson et al
 
French Hospital Database on HIV
 
415
 
285
 
0.50 (systemic only), P < .001
 
0.35, P < .001
 

p-y indicates patient-years; NR, not reported.

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