Table 1.

Demographic characteristics of CML study patients with CCR


Characteristic

Value
Median age, y (range)   51.8 (20-74)  
Sex, % male   60  
Median time from leukemia diagnosis to start of imatinib mesylate, mo (range)   8.9 (0-165)  
“Early” CML diagnosis*, %   46  
Baseline CML diagnosis, % chronic phase/% accelerated phase   85/15  
New CML (Hasford) risk scoreat diagnosis,20 %  
    Low risk   55  
    Intermediate risk   36  
    High risk   9  
Additional cytogenetic abnormalities at baseline, %   13  
Median percentage of Ph-positive metaphases at baseline (25%-75% levels)   100 (95-100)  
Average imatinib mesylate dose, mg/d  
    Chronic phase   450  
    Accelerated phase   590  
Other concomitant therapies, with imatinib mesylate, %  
    None   65  
    IFN or Ara-C   31  
    Tipifarnib   1  
    Donor leukocytes   1  
    Hsp70 vaccine   1  
Median time from start of imatinib mesylate to CCR, mo (range)   9.5 (2.4-57)  
Median time from start of imatinib mesylate to major cytogenetic response, mo (range)   5.5 (1-57)  
Median time of follow-up after imatinib mesylate, mo (range)   29 (8-59)  
Median time of follow-up after CCR, mo (range)   13 (0-32)  
Median interval between monitoring visits, mo (range)   3.2 (0.1-21)  
Median number of laboratory monitoring visits (range)
 
6 (1-16)
 

Characteristic

Value
Median age, y (range)   51.8 (20-74)  
Sex, % male   60  
Median time from leukemia diagnosis to start of imatinib mesylate, mo (range)   8.9 (0-165)  
“Early” CML diagnosis*, %   46  
Baseline CML diagnosis, % chronic phase/% accelerated phase   85/15  
New CML (Hasford) risk scoreat diagnosis,20 %  
    Low risk   55  
    Intermediate risk   36  
    High risk   9  
Additional cytogenetic abnormalities at baseline, %   13  
Median percentage of Ph-positive metaphases at baseline (25%-75% levels)   100 (95-100)  
Average imatinib mesylate dose, mg/d  
    Chronic phase   450  
    Accelerated phase   590  
Other concomitant therapies, with imatinib mesylate, %  
    None   65  
    IFN or Ara-C   31  
    Tipifarnib   1  
    Donor leukocytes   1  
    Hsp70 vaccine   1  
Median time from start of imatinib mesylate to CCR, mo (range)   9.5 (2.4-57)  
Median time from start of imatinib mesylate to major cytogenetic response, mo (range)   5.5 (1-57)  
Median time of follow-up after imatinib mesylate, mo (range)   29 (8-59)  
Median time of follow-up after CCR, mo (range)   13 (0-32)  
Median interval between monitoring visits, mo (range)   3.2 (0.1-21)  
Median number of laboratory monitoring visits (range)
 
6 (1-16)
 

N = 85. No significant difference was observed between patients with durable CCR (n = 62) and patients with disease progression (n = 23) for all listed variables. Percentages given in table are percent of total patients.

IFN indicates interferon-α; Ara-C, cytarabine.

*

< 6 months before imatinib mesylate.

Euro score.

Ph < 35%.

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