Table 1.

Liver, spleen, and hematocrit readings near death in J2Eand IFN-treated mice

Treatment groupLiver, gSpleen, gHematocrit, %
Control 1.30 ± 0.02 0.135 ± 0.007 52.5 ± 0.8 
Vehicle 1.90 ± 0.12* 0.636 ± 0.155* 39.5 ± 2.6 
A1 1.79 ± 0.04* 0.543 ± 0.072 44.9 ± 2.9 
A2 1.60 ± 0.24 0.993 ± 0.222* 36.7 ± 2.1 
A4 2.27 ± 0.14* 0.666 ± 0.229 44.1 ± 1.5* 
A5 2.59 ± 0.58 1.130 ± 0.336 36.1 ± 2.7* 
A6 1.99 ± 0.25 0.902 ± 0.232* 42.0 ± 5.8 
A9 1.58 ± 0.10 0.616 ± 0.232* 42.8 ± 2.8 
1.83 ± 0.09 0.392 ± 0.066 44.1 ± 2.5* 
Treatment groupLiver, gSpleen, gHematocrit, %
Control 1.30 ± 0.02 0.135 ± 0.007 52.5 ± 0.8 
Vehicle 1.90 ± 0.12* 0.636 ± 0.155* 39.5 ± 2.6 
A1 1.79 ± 0.04* 0.543 ± 0.072 44.9 ± 2.9 
A2 1.60 ± 0.24 0.993 ± 0.222* 36.7 ± 2.1 
A4 2.27 ± 0.14* 0.666 ± 0.229 44.1 ± 1.5* 
A5 2.59 ± 0.58 1.130 ± 0.336 36.1 ± 2.7* 
A6 1.99 ± 0.25 0.902 ± 0.232* 42.0 ± 5.8 
A9 1.58 ± 0.10 0.616 ± 0.232* 42.8 ± 2.8 
1.83 ± 0.09 0.392 ± 0.066 44.1 ± 2.5* 

As mice became moribund, blood was harvested by tail bleed; spleen and liver were removed immediately following death and weighed. Control mice received no treatment and were killed after the last mouse became moribund.

Values represent mean ± standard error.

*

Significance compared with normal mice, P < .05

P ≤.01

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