Table 1. Trough drug levels of PKC412... | American Society of Hematology

Table 1.

Trough drug levels of PKC412 and of its active metabolite GCP62221 during therapy with PKC412 in patient UPN1

Day of treatment	PKC412 trough level, ng/mL	PKC412 trough level, nM^*	CGP62221 trough level, ng/mL	CGP62221 trough level, nM^*	Sum of trough levels of PKC412 and CGP62221^*
0	0	0	0	0	0
1	8950	157.0	313	5.6	162.6
7	8660	151.9	4950	89.0	240.9
28	1070	18.8	1360	24.5	43.3
56	804	14.1	1190	21.4	35.5
84	1230	21.6	1240	22.3	43.9
119	815	14.3	1130	20.3	34.6
148	1129	19.8	1171	21.1	40.9
176	1547	27.1	1090	19.6	46.7
288	707	12.4	1790	32.2	44.6

Day of treatment	PKC412 trough level, ng/mL	PKC412 trough level, nM^*	CGP62221 trough level, ng/mL	CGP62221 trough level, nM^*	Sum of trough levels of PKC412 and CGP62221^*
0	0	0	0	0	0
1	8950	157.0	313	5.6	162.6
7	8660	151.9	4950	89.0	240.9
28	1070	18.8	1360	24.5	43.3
56	804	14.1	1190	21.4	35.5
84	1230	21.6	1240	22.3	43.9
119	815	14.3	1130	20.3	34.6
148	1129	19.8	1171	21.1	40.9
176	1547	27.1	1090	19.6	46.7
288	707	12.4	1790	32.2	44.6

Corrected for 99% protein binding¹²