Assignment to GCB or ABC subgroup according to CD10, BCL-6 and/or MUM1 expression
CD10 . | BCL-6 . | MUM1 . | Immunoprofile . | PCNSL, n (%) . |
|---|---|---|---|---|
| + | –/+ | –/+ | GCB | 2 (2.4) |
| – | + | – | GCB | 1 (1.2) |
| – | + | + | ABC | 42 (51.2) |
| – | – | –/+ | ABC | 37 (45.1) |
CD10 . | BCL-6 . | MUM1 . | Immunoprofile . | PCNSL, n (%) . |
|---|---|---|---|---|
| + | –/+ | –/+ | GCB | 2 (2.4) |
| – | + | – | GCB | 1 (1.2) |
| – | + | + | ABC | 42 (51.2) |
| – | – | –/+ | ABC | 37 (45.1) |
For PCNSL, total n = 82. Applying the Hans decision tree,8 each of our 82 patients with interpretable immunohistochemistry findings was classified as either GCB (germinal center B-cell–like) or ABC (activated B-cell–like or non-GCB) subgroup.
+ indicates positive staining; –/+, either negative or positive staining; –, negative staining.