Effect of IL-18 administration on serum levels of IFN-γ and IL-4 in the donor mice
| Group . | IFN-γ, pg/mL . | IL-4, pg/mL . |
|---|---|---|
| WT + diluent | UD | UD |
| WT + IL-18 | UD | 44 ± 9.6* |
| STAT6−/− + diluent | 143 ± 41 | UD |
| STAT6−/− + IL-18 | 2338 ± 387** | UD |
| Group . | IFN-γ, pg/mL . | IL-4, pg/mL . |
|---|---|---|
| WT + diluent | UD | UD |
| WT + IL-18 | UD | 44 ± 9.6* |
| STAT6−/− + diluent | 143 ± 41 | UD |
| STAT6−/− + IL-18 | 2338 ± 387** | UD |
Wild-type (WT) (n = 3/group) and STAT6-deficient (n = 3/group) BALB/c mice were injected with IL-18 or diluent (control) for 10 days as in “Materials and methods.” Serum was collected on the eleventh day by retro-orbital venous puncture and analyzed for IFN-γ and IL-4 by ELISA. IL-18 administration significantly increased serum levels of IL-4 (*P < .05) but did not alter IFN-γ production in the WT mice; significantly increased serum IFN-γ (**P < .03), but not IL-4, was detected in the STAT6-deficient mice.
UD indicates undetectable.