Table 1. Effect of IL-18 on the percent... | American Society of Hematology

Table 1.

Effect of IL-18 on the percent of splenic cellular phenotype

Group	Total cells	%CD4⁺	%CD8⁺	% B220⁺	%Gr-1⁺
Diluent	110.4 ± 7.8 × 10⁶	24% ± 5%	13% ± 3%	51% ± 9%	2.5% ± 0.6%
IL-18	179.8 ± 12 × 10⁶^*	19% ± 6%	9% ± 3.8%	46% ± 14%	13.4% ± 1.27%^*

Group	Total cells	%CD4⁺	%CD8⁺	% B220⁺	%Gr-1⁺
Diluent	110.4 ± 7.8 × 10⁶	24% ± 5%	13% ± 3%	51% ± 9%	2.5% ± 0.6%
IL-18	179.8 ± 12 × 10⁶^*	19% ± 6%	9% ± 3.8%	46% ± 14%	13.4% ± 1.27%^*

BALB/c mice (n = 3/group) were injected with 1 μg/day of IL-18 or the diluent (control) for 10 days. Splenocytes were harvested on day 11 and analyzed for cellular phenotype by 2-colored flow cytometry. IL-18 treatment increased the total number of cells and the percent of Gr-1 cells (

P < .03) but did not significantly alter the ratios of CD4⁺, CD8⁺, or B220⁺ cells.

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