Asparagine synthetase (AS) mRNA expression values in time
. | Day . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
. | -5 . | -4 . | -3 . | -2 . | -1 . | 0 . | |||||
| Expression of AS compared with GAPDH, % | |||||||||||
| Median | 0.26 | 0.75 | 0.75 | 0.87 | 1.05 | 0.99 | |||||
| 25th—75th percentile | 0.16-0.46 | 0.45-1.4 | 0.52-1.18 | 0.47-1.17 | 0.48-1.05 | 0.53-1.8 | |||||
| Wilcoxon signed rank test, P | |||||||||||
| Compared between successive days | NA | < .001 | .4 | .4 | .06 | .4 | |||||
| Day -5 compared with days -4, -3, -2, -1, and 0 | NA | < .001 | .001 | < .001 | .001 | .002 | |||||
. | Day . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
. | -5 . | -4 . | -3 . | -2 . | -1 . | 0 . | |||||
| Expression of AS compared with GAPDH, % | |||||||||||
| Median | 0.26 | 0.75 | 0.75 | 0.87 | 1.05 | 0.99 | |||||
| 25th—75th percentile | 0.16-0.46 | 0.45-1.4 | 0.52-1.18 | 0.47-1.17 | 0.48-1.05 | 0.53-1.8 | |||||
| Wilcoxon signed rank test, P | |||||||||||
| Compared between successive days | NA | < .001 | .4 | .4 | .06 | .4 | |||||
| Day -5 compared with days -4, -3, -2, -1, and 0 | NA | < .001 | .001 | < .001 | .001 | .002 | |||||
Median expression values (and 25th—75th percentiles of AS mRNA compared with GAPDH in time in leukemic cells of 31 children induced by pegylated L-asparaginase (PEG-Asp). Wilcoxon signed rank test compared between successive days, and day -5 values compared with levels of day -4, day -3, day -2, day -1, and day 0.
NA indicates not applicable.