Characteristics of 31 patients treated with one dose of PEG-Asp before the DCOG-ALL9 study
Characteristic . | Value . |
|---|---|
| Male/female | 17/14 |
| Age, median, y (range) | 4.2 (1.2-13.1) |
| Median WBC count at diagnosis, × 109/L (range) | 47 (11.4-417) |
| Immunophenotype | |
| Pro-B-ALL | 1 |
| Common ALL | 9 |
| Pre-B-ALL | 9 |
| T-ALL | 12 |
| Cytogenetic characteristics | |
| Hyperdiploid | 9* |
| TEL-AML 1 fusion | 5 |
| BCR-ABL fusion | 1* |
| MLL gene rearranged | 0 |
| Others | 17 |
| CNS involvement† | |
| Yes | 0 |
| No | 31 |
Characteristic . | Value . |
|---|---|
| Male/female | 17/14 |
| Age, median, y (range) | 4.2 (1.2-13.1) |
| Median WBC count at diagnosis, × 109/L (range) | 47 (11.4-417) |
| Immunophenotype | |
| Pro-B-ALL | 1 |
| Common ALL | 9 |
| Pre-B-ALL | 9 |
| T-ALL | 12 |
| Cytogenetic characteristics | |
| Hyperdiploid | 9* |
| TEL-AML 1 fusion | 5 |
| BCR-ABL fusion | 1* |
| MLL gene rearranged | 0 |
| Others | 17 |
| CNS involvement† | |
| Yes | 0 |
| No | 31 |
Patients were administered one intravenous dose of 1000 IU/m2 pegylated l-asparaginase before undergoing combination chemotherapy as part of the DCOG (Dutch Childhood Oncology Group) ALL-9 study.
One patient had both a hyperdiploidy and a BCR-ABL fusion.
CNS involvement is defined as more than 5 cells/μL with blasts in the cerebrospinal fluid.