Relative risk estimates for CHOP versus R-CHOP by Bcl-6 expression adjusting for IPI and Bcl-2 expression
. | Bcl-6+ . | . | . | Bcl-6- . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Clinical outcome . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | ||||
| FFS | ||||||||||
| R-CHOP | 1.1 | 0.6, 2.2 | .68 | 0.1 | 0.05, 0.4 | < .001 | ||||
| HI/high IPI | 3.6 | 1.5, 8.6 | .004 | 3.3 | 1.1, 10.5 | .04 | ||||
| Bcl-2+ | 1.6 | 0.9, 2.9 | .15 | 1.4 | 0.4, 4.5 | .59 | ||||
| OS | ||||||||||
| R-CHOP | 1.9 | 0.9, 3.9 | .11 | 0.1 | 0.05, 0.3 | < .001 | ||||
| HI/high IPI | 8.0 | 2.2, 28.7 | .002 | 5.9 | 1.1, 32.5 | .04 | ||||
| Bcl-2+ | 1.5 | 0.7, 2.9 | .27 | 1.0 | 0.4, 2.5 | .93 | ||||
. | Bcl-6+ . | . | . | Bcl-6- . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Clinical outcome . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | ||||
| FFS | ||||||||||
| R-CHOP | 1.1 | 0.6, 2.2 | .68 | 0.1 | 0.05, 0.4 | < .001 | ||||
| HI/high IPI | 3.6 | 1.5, 8.6 | .004 | 3.3 | 1.1, 10.5 | .04 | ||||
| Bcl-2+ | 1.6 | 0.9, 2.9 | .15 | 1.4 | 0.4, 4.5 | .59 | ||||
| OS | ||||||||||
| R-CHOP | 1.9 | 0.9, 3.9 | .11 | 0.1 | 0.05, 0.3 | < .001 | ||||
| HI/high IPI | 8.0 | 2.2, 28.7 | .002 | 5.9 | 1.1, 32.5 | .04 | ||||
| Bcl-2+ | 1.5 | 0.7, 2.9 | .27 | 1.0 | 0.4, 2.5 | .93 | ||||
Analysis removes the effect of MR to obtain unbiased estimate of induction treatment effect.