Overall test of significance of allelic heterogeneity comparing SV, LV, and combined stroke groups (MRI+) against the MRI− group for each of the 6 HLA loci
| HLA locus . | No. alleles tested (total alleles observed)* . | Log-likelihood ratio statistic (P) . | ||
|---|---|---|---|---|
| MRI+ vs MRI− . | SV vs MRI− . | LV vs MRI− . | ||
| A | 22 (37) | 41.1 (.005) | 36.6 (.04) | 36.7 (.03) |
| B | 28 (58) | 35.9 (.33) | 26.3 (.56) | 24.4 (.61) |
| C | 19 (26) | 16.5 (.62) | 19.1 (.32) | 13.7 (.72) |
| DRB1 | 24 (37) | 24.3 (.39) | 32.0 (.10) | 24.5 (.27) |
| DQB1 | 13 (17) | 16.8 (.16) | 15.9 (.20) | 14.2 (.29) |
| DPB1 | 11 (22) | 23.3 (.016) | 22.4 (.03) | 14.8 (.39) |
| HLA locus . | No. alleles tested (total alleles observed)* . | Log-likelihood ratio statistic (P) . | ||
|---|---|---|---|---|
| MRI+ vs MRI− . | SV vs MRI− . | LV vs MRI− . | ||
| A | 22 (37) | 41.1 (.005) | 36.6 (.04) | 36.7 (.03) |
| B | 28 (58) | 35.9 (.33) | 26.3 (.56) | 24.4 (.61) |
| C | 19 (26) | 16.5 (.62) | 19.1 (.32) | 13.7 (.72) |
| DRB1 | 24 (37) | 24.3 (.39) | 32.0 (.10) | 24.5 (.27) |
| DQB1 | 13 (17) | 16.8 (.16) | 15.9 (.20) | 14.2 (.29) |
| DPB1 | 11 (22) | 23.3 (.016) | 22.4 (.03) | 14.8 (.39) |
Rare alleles, occurring fewer than 3 times in the entire sample, were binned into a combined group for testing.