Mutation spectrum for patients with NRAS-mutant AML and who have the CYP1A1*2B (Val) allele
| Karyotype . | CYP1A1 allele . | Mutation: codon-base substitution/ amino acid change . |
|---|---|---|
| 5q/7q | Ile/Val | 12.2 G → A/Gly → Asp |
| 5q/7q | Ile/Val | 12.2 G → A/Gly → Asp |
| 5q/7q | Ile/Val | 61.1 C → A/Gln → Lys |
| 5q/7q | Val/Val | 12.2 G → A/Gly → Asp |
| 3q | Ile/Val | 12.1 G → A/Gly → Ser |
| 3q | Val/Val | 12.2 G → C/Gly → Ala |
| +8 | Ile/Val | 33.3 T → G/Asp → Glu |
| t(15;17) | Ile/Val | 12.1 G → A/Gly → Ser |
| Karyotype . | CYP1A1 allele . | Mutation: codon-base substitution/ amino acid change . |
|---|---|---|
| 5q/7q | Ile/Val | 12.2 G → A/Gly → Asp |
| 5q/7q | Ile/Val | 12.2 G → A/Gly → Asp |
| 5q/7q | Ile/Val | 61.1 C → A/Gln → Lys |
| 5q/7q | Val/Val | 12.2 G → A/Gly → Asp |
| 3q | Ile/Val | 12.1 G → A/Gly → Ser |
| 3q | Val/Val | 12.2 G → C/Gly → Ala |
| +8 | Ile/Val | 33.3 T → G/Asp → Glu |
| t(15;17) | Ile/Val | 12.1 G → A/Gly → Ser |