CYP1A1 allele frequency in AML patients (all cases and subgroups) with or without NRAS mutation
| . | CYP1A1 allele frequency . | |||
|---|---|---|---|---|
| Mutant NRAS,no. (%) . | No mutant NRAS, no. (%) . | OR . | 95% CI . | |
| All cases* | ||||
| Ile/Ile | 45 (84.9) | 345 (93) | 2.36 | 1.01-5.53 |
| Ile/Val or Val/Val | 8 (15.1) | 26 (7) | ||
| Good-risk karyotypes t(15;17), t(8;21), inv(16) | ||||
| Ile/Ile | 24 (96) | 190 (88) | 0.46 | 0.06-3.66 |
| Ile/Val or Val/Val | 1 (4) | 17 (12) | ||
| Intermediate karyotypes | ||||
| Ile/Ile | 13 (93) | 70 (93) | 1.08 | 0.12-9.99 |
| Ile/Val or Val/Val | 1 (7) | 5 (7) | ||
| Poor-risk karyotypes 5q/7q or 3q | ||||
| Ile/Ile | 8 (57) | 85 (96) | 15.94 | 3.71-68.52 |
| Ile/Val orVal/Val | 6 (43) | 4 (4) | ||
| . | CYP1A1 allele frequency . | |||
|---|---|---|---|---|
| Mutant NRAS,no. (%) . | No mutant NRAS, no. (%) . | OR . | 95% CI . | |
| All cases* | ||||
| Ile/Ile | 45 (84.9) | 345 (93) | 2.36 | 1.01-5.53 |
| Ile/Val or Val/Val | 8 (15.1) | 26 (7) | ||
| Good-risk karyotypes t(15;17), t(8;21), inv(16) | ||||
| Ile/Ile | 24 (96) | 190 (88) | 0.46 | 0.06-3.66 |
| Ile/Val or Val/Val | 1 (4) | 17 (12) | ||
| Intermediate karyotypes | ||||
| Ile/Ile | 13 (93) | 70 (93) | 1.08 | 0.12-9.99 |
| Ile/Val or Val/Val | 1 (7) | 5 (7) | ||
| Poor-risk karyotypes 5q/7q or 3q | ||||
| Ile/Ile | 8 (57) | 85 (96) | 15.94 | 3.71-68.52 |
| Ile/Val orVal/Val | 6 (43) | 4 (4) | ||
See Table 1 for abbreviations.
n = 424.