Deletion of donor-reactive CD4+ PBLs at week 20 in groups receiving different doses of irradiation
| Group . | CD4+ PBLs . | ||
|---|---|---|---|
| Vβ8+, % . | Vβ11+,% . | Vβ5+,% . | |
| Normal B6 | 16.9 ± 0.2 | 4.9 ± 0.3 | 1.9 ± 0.3 |
| Normal Balb/c | 17.4 ± 0.8 | 0.4 ± 0.2 | 0.0 ± 0.0 |
| 1 Gy | 17.2 ± 1.3* | 4.4 ± 1.1* | 1.3 ± 0.5* |
| 1.5 Gy | 21.5 ± 1.5 | 0.8 ± 0.2 | 0.1 ± 0.1 |
| 2 Gy | 21.8 ± 1.8 | 0.8 ± 0.3 | 0.2 ± 0.3 |
| 3 Gy | 20.4 ± 2.5 | 1.4 ± 1.5 | 0.4 ± 0.6 |
| Group . | CD4+ PBLs . | ||
|---|---|---|---|
| Vβ8+, % . | Vβ11+,% . | Vβ5+,% . | |
| Normal B6 | 16.9 ± 0.2 | 4.9 ± 0.3 | 1.9 ± 0.3 |
| Normal Balb/c | 17.4 ± 0.8 | 0.4 ± 0.2 | 0.0 ± 0.0 |
| 1 Gy | 17.2 ± 1.3* | 4.4 ± 1.1* | 1.3 ± 0.5* |
| 1.5 Gy | 21.5 ± 1.5 | 0.8 ± 0.2 | 0.1 ± 0.1 |
| 2 Gy | 21.8 ± 1.8 | 0.8 ± 0.3 | 0.2 ± 0.3 |
| 3 Gy | 20.4 ± 2.5 | 1.4 ± 1.5 | 0.4 ± 0.6 |
All mice were injected with BM and cobl. Different groups received TBI of 1, 1.5, 2, or 3 Gy on the day before BMT. Percentages shown are mean ± SD.
P < .05 for comparison of irradiated groups with the 3 Gy irradiated (standard-protocol) group.