Spleen weight, total femoral BM nucleated cell count, and clonogenicity for different treatments evaluated 360 days after irradiation
| Treatment group . | UC (n = 4) . | 5F (n = 17) . | 4F (n = 8) . | TPO (n = 5) . | SDF-1 (n = 4) . |
|---|---|---|---|---|---|
| Spleen weight | 62.8 ± 5.1 | 49.4 ± 15.1 | 54.9 ± 21.6 | 56 ± 22.6 | 48.5 ± 15.7 |
| Range | 56-68 | 36-101 | 28-96 | 31-96 | 31-69 |
| Median | 63.5 | 46 | 51 | 46 | 47 |
| BM TNC | 43.4 ± 6.4 | 28 ± 13.6 | 33.6 ± 5.8 | 33.1 ± 3.4 | 26.7 ± 6.5 |
| Range | 34.4-48.4 | 14.4-47.6 | 25-42.6 | 31-38.8 | 18-32.8 |
| Median | 45.4 | 24 | 33.8 | 31.2 | 28 |
| (%) | (100) | (64.5) | (77.4) | (76.3) | (61.5) |
| Total BM CFU | 143.7 ± 24.3 | 40 ± 24.7 | 80.6 ± 19.1 | 84.9 ± 8.6 | 63.4 ± 13.4 |
| Range | 121.5-173.6 | 19.7-54.7 | 59.7-113 | 79.6-99.6 | 44.4-74.5 |
| Median | 139.8 | 41 | 75.3 | 80.1 | 67.3 |
| (%) | (100) | (27.8) | (56.1) | (59.1) | (44.1) |
| Treatment group . | UC (n = 4) . | 5F (n = 17) . | 4F (n = 8) . | TPO (n = 5) . | SDF-1 (n = 4) . |
|---|---|---|---|---|---|
| Spleen weight | 62.8 ± 5.1 | 49.4 ± 15.1 | 54.9 ± 21.6 | 56 ± 22.6 | 48.5 ± 15.7 |
| Range | 56-68 | 36-101 | 28-96 | 31-96 | 31-69 |
| Median | 63.5 | 46 | 51 | 46 | 47 |
| BM TNC | 43.4 ± 6.4 | 28 ± 13.6 | 33.6 ± 5.8 | 33.1 ± 3.4 | 26.7 ± 6.5 |
| Range | 34.4-48.4 | 14.4-47.6 | 25-42.6 | 31-38.8 | 18-32.8 |
| Median | 45.4 | 24 | 33.8 | 31.2 | 28 |
| (%) | (100) | (64.5) | (77.4) | (76.3) | (61.5) |
| Total BM CFU | 143.7 ± 24.3 | 40 ± 24.7 | 80.6 ± 19.1 | 84.9 ± 8.6 | 63.4 ± 13.4 |
| Range | 121.5-173.6 | 19.7-54.7 | 59.7-113 | 79.6-99.6 | 44.4-74.5 |
| Median | 139.8 | 41 | 75.3 | 80.1 | 67.3 |
| (%) | (100) | (27.8) | (56.1) | (59.1) | (44.1) |
Parameters were evaluated in long-term survivors versus age-matched unirradiated controls (UC). Results are expressed as follows: spleen weight in mg; BM total nucleated cell count in million cells from 2 femurs following erythrocyte lysis; total BM CFU × 10−3 per mouse (GM-CFU + BFU-e) enumerated after 10 days of culture in semisolid medium. The only irradiated animal surviving at 360 days exhibited the following values: spleen weight, 48 mg; femoral BM TNC, 20.6 × 106cells; BM CFU, 48,753.