Table 4.

Spleen weight, total femoral BM nucleated cell count, and clonogenicity for different treatments evaluated 360 days after irradiation

Treatment groupUC (n = 4)5F (n = 17)4F (n = 8)TPO (n = 5)SDF-1 (n = 4)
Spleen weight 62.8 ± 5.1 49.4 ± 15.1 54.9 ± 21.6 56 ± 22.6 48.5 ± 15.7 
 Range 56-68 36-101 28-96 31-96 31-69 
 Median 63.5 46 51 46 47  
BM TNC 43.4 ± 6.4 28 ± 13.6 33.6 ± 5.8 33.1 ± 3.4 26.7 ± 6.5 
 Range 34.4-48.4 14.4-47.6 25-42.6 31-38.8 18-32.8 
 Median 45.4 24 33.8 31.2 28 
 (%) (100) (64.5) (77.4) (76.3) (61.5)  
Total BM CFU 143.7 ± 24.3 40 ± 24.7 80.6 ± 19.1 84.9 ± 8.6 63.4 ± 13.4 
 Range 121.5-173.6 19.7-54.7 59.7-113 79.6-99.6 44.4-74.5 
 Median 139.8 41 75.3 80.1 67.3 
 (%) (100) (27.8) (56.1) (59.1) (44.1) 
Treatment groupUC (n = 4)5F (n = 17)4F (n = 8)TPO (n = 5)SDF-1 (n = 4)
Spleen weight 62.8 ± 5.1 49.4 ± 15.1 54.9 ± 21.6 56 ± 22.6 48.5 ± 15.7 
 Range 56-68 36-101 28-96 31-96 31-69 
 Median 63.5 46 51 46 47  
BM TNC 43.4 ± 6.4 28 ± 13.6 33.6 ± 5.8 33.1 ± 3.4 26.7 ± 6.5 
 Range 34.4-48.4 14.4-47.6 25-42.6 31-38.8 18-32.8 
 Median 45.4 24 33.8 31.2 28 
 (%) (100) (64.5) (77.4) (76.3) (61.5)  
Total BM CFU 143.7 ± 24.3 40 ± 24.7 80.6 ± 19.1 84.9 ± 8.6 63.4 ± 13.4 
 Range 121.5-173.6 19.7-54.7 59.7-113 79.6-99.6 44.4-74.5 
 Median 139.8 41 75.3 80.1 67.3 
 (%) (100) (27.8) (56.1) (59.1) (44.1) 

Parameters were evaluated in long-term survivors versus age-matched unirradiated controls (UC). Results are expressed as follows: spleen weight in mg; BM total nucleated cell count in million cells from 2 femurs following erythrocyte lysis; total BM CFU × 10−3 per mouse (GM-CFU + BFU-e) enumerated after 10 days of culture in semisolid medium. The only irradiated animal surviving at 360 days exhibited the following values: spleen weight, 48 mg; femoral BM TNC, 20.6 × 106cells; BM CFU, 48,753.

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