Survival percentages at 30 and 300 days after TBI for the different treatments
| Survival, d . | Control n = 120 . | Treatment . | ||||||
|---|---|---|---|---|---|---|---|---|
| TPO n = 24 . | 4Fsingle n = 24 . | 4F n = 48 . | 5F n = 48 . | 4F 10 n = 24 . | 3F n = 24 . | SDF-1 n = 24 . | ||
| 30 | 8.3 | 58.3 | 62.50 | 81.25 | 87.5 | 45.8 | 50.0 | 29.2 |
| 300 | 3.3 | 29.2 | 41.7 | 50.0 | 43.8 | 8.3 | 20.8 | 12.5 |
| Survival, d . | Control n = 120 . | Treatment . | ||||||
|---|---|---|---|---|---|---|---|---|
| TPO n = 24 . | 4Fsingle n = 24 . | 4F n = 48 . | 5F n = 48 . | 4F 10 n = 24 . | 3F n = 24 . | SDF-1 n = 24 . | ||
| 30 | 8.3 | 58.3 | 62.50 | 81.25 | 87.5 | 45.8 | 50.0 | 29.2 |
| 300 | 3.3 | 29.2 | 41.7 | 50.0 | 43.8 | 8.3 | 20.8 | 12.5 |
TPO or SDF-1 indicates each cytokine alone; 3F, SCF + FLT-3 ligand + TPO; 4F, 3F + IL-3; 5F, 4F + SDF-1. TPO, SDF-1, 3F, 4F, and 5F were given 2 hours and 24 hours after TBI. Each cytokine was administered at 50 μg/kg. 4Fsingle is 4F given only at 2 hours after TBI. Each cytokine was given at 50 μg/kg. 4F10 is 4F given at 2 hours and 24 hours after TBI. Each cytokine was given at 10 μg/kg. Control, irradiated controls treated with cytokine diluent. The number (n) of mice for each group is indicated. See Table 2 for statistical significance.