Unmodified MV-Edm and the recombinant MV-αCD38 virus were equally cytotoxic for myeloma cell lines and caused minimal cell death in nontransformed PHA-stimulated PBLs
| Cells . | CD38 status . | Cytotoxicity, % cell death . | |
|---|---|---|---|
| MV-Edm . | MV-αCD38 . | ||
| ARH-77 | ++ | 87.6 | 88.2 |
| JJN-3 | + | 68.7 | 49.8 |
| RPMI 8226 | + | 71.2 | 70.5 |
| MM-1 | ++ | 75.6 | 85.9 |
| KAS 6/1 | + | 30.0 | 31.4 |
| PBLs* | + | <1.0 | <1.0 |
| Cells . | CD38 status . | Cytotoxicity, % cell death . | |
|---|---|---|---|
| MV-Edm . | MV-αCD38 . | ||
| ARH-77 | ++ | 87.6 | 88.2 |
| JJN-3 | + | 68.7 | 49.8 |
| RPMI 8226 | + | 71.2 | 70.5 |
| MM-1 | ++ | 75.6 | 85.9 |
| KAS 6/1 | + | 30.0 | 31.4 |
| PBLs* | + | <1.0 | <1.0 |
Cells were infected with either viruses at MOI of 1.0 and cell death was determined at 6 days after infection. Results are average of 2 different experiments. Cell death was expressed as a percentage of the respective uninfected controls.
MOI = 3.0.