Comparison of results in cobalamin-deficient (pernicious anemia) patients with neurologic abnormalities only, hematologic abnormalities only, or both
| . | Manifestations of cobalamin deficiency . | P3-150 . | ||
|---|---|---|---|---|
| . | Neurologic only, n = 5 . | Anemia only, n = 11 . | Both, n = 6 . | |
| tHcy level, μM | 45.8 ± 34.9 | 98.5 ± 50.1 | 140.8 ± 38.5 | .008 |
| AdoMet level, nM | 126.0 ± 12.3 | 78.6 ± 26.6 | 109.9 ± 30.9 | .006 |
| Methionine level, μM | 24.0 ± 13.6 | 23.8 ± 9.7 | 17.9 ± 7.1 | NS |
| Cysteine level, μM | 503 ± 83 | 325 ± 73 | 421 ± 84 | .002 |
| Cys-gly level, μM | 82.6 ± 9.7 | 54.7 ± 13.0 | 87.4 ± 35.3 | .009 |
| GSH level, μM | 3.3 ± 1.2 | 1.9 ± 1.2 | 1.3 ± 0.8 | .03 |
| Cobalamin level, pM | 39 ± 43 | 35 ± 39 | 27 ± 13 | NS |
| Folate level, nM | 30.1 ± 13.1 | 15.4 ± 7.5 | 26.3 ± 12.9 | .048 |
| Hemoglobin level, g/L | 148 ± 10 | 63 ± 31 | 81 ± 38 | .001 |
| MCV, fL | 97 ± 9 | 109 ± 14 | 117 ± 19 | NS |
| . | Manifestations of cobalamin deficiency . | P3-150 . | ||
|---|---|---|---|---|
| . | Neurologic only, n = 5 . | Anemia only, n = 11 . | Both, n = 6 . | |
| tHcy level, μM | 45.8 ± 34.9 | 98.5 ± 50.1 | 140.8 ± 38.5 | .008 |
| AdoMet level, nM | 126.0 ± 12.3 | 78.6 ± 26.6 | 109.9 ± 30.9 | .006 |
| Methionine level, μM | 24.0 ± 13.6 | 23.8 ± 9.7 | 17.9 ± 7.1 | NS |
| Cysteine level, μM | 503 ± 83 | 325 ± 73 | 421 ± 84 | .002 |
| Cys-gly level, μM | 82.6 ± 9.7 | 54.7 ± 13.0 | 87.4 ± 35.3 | .009 |
| GSH level, μM | 3.3 ± 1.2 | 1.9 ± 1.2 | 1.3 ± 0.8 | .03 |
| Cobalamin level, pM | 39 ± 43 | 35 ± 39 | 27 ± 13 | NS |
| Folate level, nM | 30.1 ± 13.1 | 15.4 ± 7.5 | 26.3 ± 12.9 | .048 |
| Hemoglobin level, g/L | 148 ± 10 | 63 ± 31 | 81 ± 38 | .001 |
| MCV, fL | 97 ± 9 | 109 ± 14 | 117 ± 19 | NS |
tHcy indicates total homocysteine; AdoMet,S-adenosylmethionine; cys-gly, cysteinylglycine; GSH, glutathione; and NS, not significant.
All levels for which P is given are significant.